O43734 · CIKS_HUMAN
- ProteinE3 ubiquitin ligase TRAF3IP2
- GeneTRAF3IP2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids574 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828).
Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828).
Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361).
Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828).
Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828).
Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361).
Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828).
Catalytic activity
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin ligase TRAF3IP2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO43734
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Involvement in disease
Psoriasis 13 (PSORS13)
- Note
- DescriptionA common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
- See alsoMIM:614070
Candidiasis, familial, 8 (CANDF8)
- Note
- DescriptionA primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
- See alsoMIM:615527
Natural variants in CANDF8
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_070904 | 536 | T>I | in CANDF8; abolishes homotypic interactions with the SEFIR domain of IL17RA, IL17RB and IL17RC; does not affect homodimerization; does not affect SEFIR-independent interactions with other proteins; dbSNP:rs397518485 |
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | VAR_047349 | 19 | likely risk factor for PSORS13; there is a reducing binding of this variant to TRAF6; dbSNP:rs33980500 | ||
Natural variant | VAR_031227 | 83 | in dbSNP:rs13190932 | ||
Mutagenesis | 303 | Loss of E3 ubiquitin ligase activity. | |||
Mutagenesis | 318 | Decreases E3 ubiquitin ligase activity. | |||
Mutagenesis | 319 | Loss of E3 ubiquitin ligase activity. | |||
Mutagenesis | 324 | Decreases E3 ubiquitin ligase activity. | |||
Natural variant | VAR_024307 | 332 | in dbSNP:rs1043730 | ||
Natural variant | VAR_070904 | 536 | in CANDF8; abolishes homotypic interactions with the SEFIR domain of IL17RA, IL17RB and IL17RC; does not affect homodimerization; does not affect SEFIR-independent interactions with other proteins; dbSNP:rs397518485 | ||
Variants
![](/variants.8e7f84.jpg)
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 586 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Chain | PRO_0000089751 | 1-574 | UniProt | E3 ubiquitin ligase TRAF3IP2 | ||
Modified residue (large scale data) | 36 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 383 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 558 | PRIDE | Phosphotyrosine | |||
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta (PubMed:12459498).
Interacts with TRAF6; this interaction is direct (PubMed:12459498, PubMed:19825828).
Interacts with IL17RA and IL17RC (PubMed:19825828, PubMed:24120361, PubMed:33723527).
Interacts with IL17RB (PubMed:24120361).
Interacts with TRAF6; this interaction is direct (PubMed:12459498, PubMed:19825828).
Interacts with IL17RA and IL17RC (PubMed:19825828, PubMed:24120361, PubMed:33723527).
Interacts with IL17RB (PubMed:24120361).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | O43734 | FHL3 Q96C98 | 3 | EBI-744798, EBI-10229248 | |
BINARY | O43734 | MRPL28 Q13084 | 3 | EBI-744798, EBI-723426 | |
BINARY | O43734 | RIMBP3 Q9UFD9 | 3 | EBI-744798, EBI-10182375 | |
BINARY | O43734 | STK16 O75716 | 3 | EBI-744798, EBI-749295 | |
BINARY | O43734 | TRAF6 Q9Y4K3 | 4 | EBI-744798, EBI-359276 | |
BINARY | O43734 | TRIP6 Q15654 | 3 | EBI-744798, EBI-742327 |
Complex viewer
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-67 | Disordered | |||
Region | 1-256 | Mediates interaction with TRAF6 | |||
Compositional bias | 52-67 | Polar residues | |||
Region | 155-211 | Disordered | |||
Compositional bias | 170-186 | Polar residues | |||
Region | 327-403 | Disordered | |||
Compositional bias | 378-394 | Pro residues | |||
Domain | 409-550 | SEFIR | |||
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
O43734-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsC6ORF4
- Length574
- Mass (Da)64,666
- Last updated2011-01-11 v3
- MD5 ChecksumFEFA5D07A8E4A7D1F2D6241664011DF3
O43734-2
- Name2
- SynonymsC6ORF5, C6ORF6
- Differences from canonical
- 1-9: Missing
O43734-3
- Name3
- Differences from canonical
- 1-421: Missing
O43734-4
- Name4
- Differences from canonical
- 1-465: Missing
O43734-5
- Name5
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8V8TQD6 | A0A8V8TQD6_HUMAN | TRAF3IP2 | 585 | ||
A0A494C1J9 | A0A494C1J9_HUMAN | TRAF3IP2 | 105 | ||
A0A494C0I3 | A0A494C0I3_HUMAN | TRAF3IP2 | 41 | ||
A0A494C0G2 | A0A494C0G2_HUMAN | TRAF3IP2 | 61 | ||
A0A494C0R7 | A0A494C0R7_HUMAN | TRAF3IP2 | 67 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_004163 | 1-9 | in isoform 2 and isoform 5 | ||
Alternative sequence | VSP_035733 | 1-421 | in isoform 3 | ||
Alternative sequence | VSP_040374 | 1-465 | in isoform 4 | ||
Compositional bias | 52-67 | Polar residues | |||
Compositional bias | 170-186 | Polar residues | |||
Sequence conflict | 334 | in Ref. 3; AAG15407 | |||
Sequence conflict | 347 | in Ref. 1; AAF67447 | |||
Compositional bias | 378-394 | Pro residues | |||
Alternative sequence | VSP_047098 | 463 | in isoform 5 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF136405 EMBL· GenBank· DDBJ | AAF67445.1 EMBL· GenBank· DDBJ | mRNA | ||
AF136406 EMBL· GenBank· DDBJ | AAF67446.1 EMBL· GenBank· DDBJ | mRNA | ||
AF136407 EMBL· GenBank· DDBJ | AAF67447.1 EMBL· GenBank· DDBJ | mRNA | ||
AF274303 EMBL· GenBank· DDBJ | AAG15367.1 EMBL· GenBank· DDBJ | mRNA | ||
AF272151 EMBL· GenBank· DDBJ | AAG15407.1 EMBL· GenBank· DDBJ | mRNA | ||
AK025351 EMBL· GenBank· DDBJ | BAB15117.1 EMBL· GenBank· DDBJ | mRNA | ||
AK026602 EMBL· GenBank· DDBJ | BAB15507.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK314415 EMBL· GenBank· DDBJ | BAG37036.1 EMBL· GenBank· DDBJ | mRNA | ||
AL050289 EMBL· GenBank· DDBJ | CAB43390.1 EMBL· GenBank· DDBJ | mRNA | ||
AL008730 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
Z97989 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471051 EMBL· GenBank· DDBJ | EAW48285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471051 EMBL· GenBank· DDBJ | EAW48287.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC002823 EMBL· GenBank· DDBJ | AAH02823.1 EMBL· GenBank· DDBJ | mRNA | ||
BI856094 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |