Activation of GalR2 leads to elevation of intracellular Ca(2+) due to Ca(2+) efflux from endoplasmic reticulum through IP3R sequentially opening BK alpha channels.
The expression of GALR2 mRNA is lost in head and neck squamous cell carcinoma as a consequence of DNA methylation.Silencing of the GALR2 gene by methylation may be a critical event in head and neck squamous cell carcinoma.
galanin receptor 2 promotes cell proliferation and survival and promotes tumor growth consistent with an oncogenic role for GALR2 in squamous cell carcinoma of the head and neck
Not Associated with CHEMDEPENDENCY: alcoholism., There was no effect of GALR2 on alcoholism risk; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
study indicates that a high level of GalR2 galanin receptor expression is able to inhibit cell proliferation and induce apoptosis in neuroblastoma cells
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