Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.
Galanin Receptors (GalR1 GalR2 and GalR3) Expression in Colorectal Cancer Tissue and Correlations to the Overall Survival and Poor Prognosis of CRC Patients.
Variants in genes for galanin (GAL) and its receptors (GALR1 GALR2 GALR3) despite their disparate genomic loci conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events.
Activation of GalR2 leads to elevation of intracellular Ca(2+) due to Ca(2+) efflux from endoplasmic reticulum through IP3R sequentially opening BK alpha channels.
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