O43300 · LRRT2_HUMAN

  • Protein
    Leucine-rich repeat transmembrane neuronal protein 2
  • Gene
    LRRTM2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in the development and maintenance of excitatory synapses in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexcitatory synapse
Cellular Componentextracellular space
Cellular ComponentGABA-ergic synapse
Cellular Componentglutamatergic synapse
Cellular Componenthippocampal mossy fiber to CA3 synapse
Cellular Componentpostsynaptic density membrane
Cellular Componentpostsynaptic specialization membrane
Cellular ComponentSchaffer collateral - CA1 synapse
Molecular Functionneurexin family protein binding
Biological Processlong-term synaptic potentiation
Biological Processnegative regulation of receptor internalization
Biological Processpositive regulation of synapse assembly
Biological Processregulation of postsynaptic density assembly
Biological Processsynapse organization

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Leucine-rich repeat transmembrane neuronal protein 2
  • Alternative names
    • Leucine-rich repeat neuronal 2 protein

Gene names

    • Name
      LRRTM2
    • Synonyms
      KIAA0416, LRRN2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O43300
  • Secondary accessions
    • A0AVL3
    • A8K4U9
    • B7ZLN8
    • Q7L770

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain34-422Extracellular
Transmembrane423-443Helical
Topological domain444-516Cytoplasmic

Keywords

Disease & Variants

Variants

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The viewer provides 431 variants from UniProt as well as other sources including ClinVar and dbSNP.

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Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-33
ChainPRO_000001835334-516Leucine-rich repeat transmembrane neuronal protein 2
Glycosylation57N-linked (GlcNAc...) asparagine
Glycosylation126N-linked (GlcNAc...) asparagine
Glycosylation243N-linked (GlcNAc...) asparagine
Glycosylation362N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in neuronal tissues.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with DLG4. Interacts with neurexin NRXN1; interaction is mediated by heparan sulfate glycan modification on neurexin.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY O43300TMEM120B A0PK003EBI-18096461, EBI-10171534
BINARY O43300TNF P013753EBI-18096461, EBI-359977

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, repeat, motif.

TypeIDPosition(s)Description
Domain34-61LRRNT
Repeat63-83LRR 1
Repeat86-107LRR 2
Repeat110-131LRR 3
Repeat134-155LRR 4
Repeat158-179LRR 5
Repeat182-203LRR 6
Repeat206-227LRR 7
Repeat230-251LRR 8
Repeat254-275LRR 9
Repeat278-299LRR 10
Domain311-362LRRCT
Motif513-516Involved in DLG4-binding

Domain

Synaptogenic effects are mediated by the extracellular LRR region.

Sequence similarities

Belongs to the LRRTM family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    516
  • Mass (Da)
    59,076
  • Last updated
    2004-07-19 v3
  • Checksum
    F2EDD45C854BC3A6
MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLCWNLSTTVTVMATTYRDPTTEYTKRISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIFTQRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLRSQTRLHMSNMSDQGPYNEYEPTHEGPFIIINGYGQCKCQQLPYKECEV

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E5RIQ2E5RIQ2_HUMANLRRTM238
E5RHE5E5RHE5_HUMANLRRTM277

Sequence caution

The sequence BAA24846.2 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict334in Ref. 3; BAF83753

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY182026
EMBL· GenBank· DDBJ
AAO67547.1
EMBL· GenBank· DDBJ
mRNA
AB007876
EMBL· GenBank· DDBJ
BAA24846.2
EMBL· GenBank· DDBJ
mRNA Different initiation
AK291064
EMBL· GenBank· DDBJ
BAF83753.1
EMBL· GenBank· DDBJ
mRNA
BC126408
EMBL· GenBank· DDBJ
AAI26409.1
EMBL· GenBank· DDBJ
mRNA
BC126410
EMBL· GenBank· DDBJ
AAI26411.1
EMBL· GenBank· DDBJ
mRNA
BC143926
EMBL· GenBank· DDBJ
AAI43927.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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