O43147 · SGSM2_HUMAN
- ProteinSmall G protein signaling modulator 2
- GeneSGSM2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1006 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:21808068, PubMed:26620560).
Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560).
Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | melanosome | |
Molecular Function | GTPase activator activity | |
Molecular Function | small GTPase binding | |
Biological Process | late endosome to Golgi transport | |
Biological Process | positive regulation of GTPase activity |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSmall G protein signaling modulator 2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO43147
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Melanosomal localization is mediated by RAB9A.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_031795 | 63 | in dbSNP:rs17853891 | |||
Sequence: L → M | ||||||
Natural variant | VAR_031796 | 238 | in dbSNP:rs745400 | |||
Sequence: R → K | ||||||
Natural variant | VAR_031797 | 244 | in dbSNP:rs17853888 | |||
Sequence: R → S | ||||||
Natural variant | VAR_031798 | 329 | in dbSNP:rs17857178 | |||
Sequence: H → R | ||||||
Natural variant | VAR_031799 | 374 | in dbSNP:rs2248821 | |||
Sequence: R → Q | ||||||
Mutagenesis | 803 | Loss of GTPase activator activity towards RAB32, RAB33B and RAB38. | ||||
Sequence: R → A | ||||||
Natural variant | VAR_031800 | 968 | in dbSNP:rs17857180 | |||
Sequence: D → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,328 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000284662 | 1-1006 | UniProt | Small G protein signaling modulator 2 | |||
Sequence: MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRIIYPGHRHEHNAGDMIEMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK | |||||||
Modified residue (large scale data) | 123 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 402 | UniProt | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 34-191 | RUN | ||||
Sequence: HEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADH | ||||||
Compositional bias | 96-112 | Polar residues | ||||
Sequence: AEGRKPSGVSQEALRRQ | ||||||
Region | 96-120 | Disordered | ||||
Sequence: AEGRKPSGVSQEALRRQGSASGKAP | ||||||
Region | 205-232 | Disordered | ||||
Sequence: HRIRGPPTRQDSPAKRPALGIRKRHSSG | ||||||
Domain | 566-939 | Rab-GAP TBC | ||||
Sequence: GIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAAR | ||||||
Region | 657-768 | Disordered | ||||
Sequence: FISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAGEL | ||||||
Compositional bias | 690-727 | Polar residues | ||||
Sequence: AVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQ |
Domain
The Rab-GAP TBC domain possesses GTPase activator activity.
Sequence similarities
Belongs to the RUTBC family.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
O43147-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,006
- Mass (Da)113,285
- Last updated2007-04-17 v4
- Checksum352F6F6D6017B570
O43147-2
- Name2
- Differences from canonical
- 430-430: N → ITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKD
O43147-3
- Name3
O43147-5
- Name5
- Differences from canonical
- 978-1006: ERAEHHDAQEILRIARDLVHKVQMLIENK → GTSLKTTCKK
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_024594 | 1-412 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 96-112 | Polar residues | ||||
Sequence: AEGRKPSGVSQEALRRQ | ||||||
Sequence conflict | 159 | in Ref. 4; BAG58030 | ||||
Sequence: E → G | ||||||
Alternative sequence | VSP_024595 | 413-430 | in isoform 3 | |||
Sequence: ATDYVFRIIYPGHRHEHN → MLSMICSRNLTAPNPMKD | ||||||
Alternative sequence | VSP_024596 | 430 | in isoform 2 | |||
Sequence: N → ITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKD | ||||||
Alternative sequence | VSP_024597 | 552-569 | in isoform 3 | |||
Sequence: NYKELELLRQVYYGGIEH → VPTLGFQGHRSRGWGGQE | ||||||
Alternative sequence | VSP_024598 | 570-1006 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 690-727 | Polar residues | ||||
Sequence: AVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQ | ||||||
Alternative sequence | VSP_035964 | 978-1006 | in isoform 5 | |||
Sequence: ERAEHHDAQEILRIARDLVHKVQMLIENK → GTSLKTTCKK |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB275762 EMBL· GenBank· DDBJ | BAF63512.1 EMBL· GenBank· DDBJ | mRNA | ||
AB007857 EMBL· GenBank· DDBJ | BAA23693.3 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK125203 EMBL· GenBank· DDBJ | BAC86084.1 EMBL· GenBank· DDBJ | mRNA | ||
AK294955 EMBL· GenBank· DDBJ | BAG58030.1 EMBL· GenBank· DDBJ | mRNA | ||
AC006435 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL450226 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC039204 EMBL· GenBank· DDBJ | AAH39204.1 EMBL· GenBank· DDBJ | mRNA | ||
BC040590 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |