O43101 · CBF5_CANAL

Function

function

Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site96Nucleophile

GO annotations

AspectTerm
Cellular Componentbox H/ACA snoRNP complex
Cellular Componentmicrotubule
Molecular FunctionDNA binding
Molecular Functionpseudouridine synthase activity
Molecular FunctionRNA binding
Molecular FunctionsnRNA pseudouridine synthase activity
Biological Processbox H/ACA sno(s)RNA 3'-end processing
Biological ProcessmRNA pseudouridine synthesis
Biological ProcessrRNA pseudouridine synthesis
Biological ProcesssnoRNA guided rRNA pseudouridine synthesis
Biological ProcesssnRNA pseudouridine synthesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    H/ACA ribonucleoprotein complex subunit CBF5
  • EC number
  • Alternative names
    • Centromere-binding factor 5
    • H/ACA snoRNP protein CBF5
    • Small nucleolar RNP protein CBF5

Gene names

    • Name
      CBF5
    • ORF names
      CaO19.1833, CaO19.9391
    • Ordered locus names
      CAALFM_C110620WA

Organism names

Accessions

  • Primary accession
    O43101
  • Secondary accessions
    • A0A1D8PEX8
    • Q59LW9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001219781-479H/ACA ribonucleoprotein complex subunit CBF5

Interaction

Subunit

Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain267-342PUA
Region358-479Disordered
Compositional bias361-395Basic and acidic residues
Compositional bias412-473Basic and acidic residues

Sequence similarities

Belongs to the pseudouridine synthase TruB family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    479
  • Mass (Da)
    54,322
  • Last updated
    1998-06-01 v1
  • Checksum
    3BAF5104E12C9EB6
MSSKEDYIIKPESVSPSNDTSQWPLLLKNYDKLLVRSGHYTPIPAGSAPLNRDIKSYVSSGVINLDKPSNPSSHEVVAWIKRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHEQLKDDKELNRALENLTGALFQRPPLISAVKRQLRVRTVYDSKLIEFDNKRGLGVFWASCEAGTYMRTLCVHLGMLLGVGGHMQELRRVRSGAMSESDNLVTLHDVLDAQYVYDNTRDESYLRKIIQPLESLLVGYKRVVVKDSAVNSVCYGAKLMIPGLLRYEEGIELYDEVVLMTTKGEAIAIGIAQMSTVDLQSCDHGIVAKVKRCIMERDTYPRRWGLGPIAQKKKQMKADGKLDKYGRVNENTPENWKKDYKDLDEQPAPPIPESKLVAPEPQLPKKKSLIEEVEVDIDVEDKSEKKEKKDKKEKKEKKDKKEKKEKKDKKEKKRKAEDDSSKSEKKKKSKKD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias361-395Basic and acidic residues
Compositional bias412-473Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U59149
EMBL· GenBank· DDBJ
AAB94297.1
EMBL· GenBank· DDBJ
Genomic DNA
CP017623
EMBL· GenBank· DDBJ
AOW26689.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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