O43100 · CBF5_EMENI

Function

function

Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site96Nucleophile

GO annotations

AspectTerm
Cellular Componentbox H/ACA snoRNP complex
Cellular Componentmicrotubule
Molecular FunctionDNA binding
Molecular Functionpseudouridine synthase activity
Molecular Functionpseudouridylate synthase activity
Molecular FunctionRNA binding
Molecular FunctionsnRNA pseudouridine synthase activity
Biological Processanisotropic cell growth
Biological Processbox H/ACA sno(s)RNA 3'-end processing
Biological Processconidium formation
Biological Processendocytosis
Biological Processestablishment of cell polarity
Biological ProcessmRNA pseudouridine synthesis
Biological ProcessrRNA pseudouridine synthesis
Biological ProcesssnRNA pseudouridine synthesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    H/ACA ribonucleoprotein complex subunit CBF5
  • EC number
  • Alternative names
    • Centromere-binding factor 5
    • H/ACA snoRNP protein CBF5
    • Small nucleolar RNP protein CBF5
    • rRNA pseudouridine synthase

Gene names

    • Name
      cbf5
    • Synonyms
      swoC
    • ORF names
      AN8851

Organism names

Accessions

  • Primary accession
    O43100
  • Secondary accessions
    • C8V9H8
    • Q541P5
    • Q5AS79

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001219791-481H/ACA ribonucleoprotein complex subunit CBF5

Interaction

Subunit

Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain268-343PUA
Region387-481Disordered
Compositional bias408-456Basic and acidic residues
Compositional bias466-481Basic and acidic residues

Sequence similarities

Belongs to the pseudouridine synthase TruB family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    481
  • Mass (Da)
    54,204
  • Last updated
    1998-06-01 v1
  • Checksum
    A671BB6C57CE9590
MAKEVDYTIKPEATASNINTEDWPLLLKNYDKLMVRTGHFTPIPAGSSPLKRDLKSYINSGVINLDKPSNPSSHEVVAWMKRILRAEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKIPGGEAQFKRALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERHLGVFWVSCEAGTYIRTLCVHLGLLLGVGAHMQELRRVRSGAMSENEGMVTLHDVLDAQWLYDNQRDESYLRKVIKPLESLLTTYKRIVVKDSAVNAVCYGAKLMIPGLLRFEAGIELGEEVVLMTTKGEAIAIGIAQMSTVELSTCDHGVVAKVKRCIMERDLYPRRWGLGPVALEKKKLKSSGKLDKYGRANEATPAKWKSEYKDYSAPDGDSSQQAVDVVAKEEASPKEEPSLEANESKMDIDDAQDDEDKKKRKRHEGETPEERAERKRKKKEKKEKKERRKSKQEKDDSDDSD

Sequence caution

The sequence EAA60139.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias408-456Basic and acidic residues
Compositional bias466-481Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U59148
EMBL· GenBank· DDBJ
AAB94296.1
EMBL· GenBank· DDBJ
mRNA
AY057454
EMBL· GenBank· DDBJ
AAL23694.1
EMBL· GenBank· DDBJ
Genomic DNA
AACD01000163
EMBL· GenBank· DDBJ
EAA60139.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
BN001303
EMBL· GenBank· DDBJ
CBF77883.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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