O42721 · MP1_TALMA

Function

function

Constitutive protein of the cell wall. Binds fatty acids and may thus serve as a fatty acid transporter between P.marneffei and host cells during infection (PubMed:20053994).
Abundant antigen target of host humoral immune response (PubMed:9488383).

Biotechnology

An enzyme-linked immunosorbent assay (ELISA) with antibodies against Mp1 protein as well as Mp1 antigen-based ELISA can be used to detect infections caused by P.marneffei (penicilliosis).

Features

Showing features for binding site.

146250100150200250300350400450
TypeIDPosition(s)Description
Binding site313hexadecanoate (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentfungal-type cell wall
Cellular Componenthyphal cell wall
Cellular Componentyeast-form cell wall
Molecular Functionfatty acid binding
Molecular Functionstructural constituent of cell wall
Biological Processfungal-type cell wall organization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cell wall mannoprotein 1

Gene names

    • Name
      MP1

Organism names

  • Taxonomic identifier
  • Strain
    • PM4
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Trichocomaceae > Talaromyces > Talaromyces sect. Talaromyces

Accessions

  • Primary accession
    O42721

Organism-specific databases

Subcellular Location

Secreted, cell wall
Note: Associated with the entire thickness of the cell walls of yeast and conidia found in mold form. Localizes on the outer layers of the hyphal cell walls.

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis3132-fold increase in affinity for palmitic acid. Decreased binding affinity for palmitic acid; when associated with A-332.
Mutagenesis332Decreased binding affinity for palmitic acid; when associated with A-313.

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-18
ChainPRO_000043278119-462Cell wall mannoprotein 1

Post-translational modification

Mannoprotein, glycosylated.

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region346-429Disordered
Compositional bias396-429Polar residues

Sequence similarities

Belongs to the cell wall mannoprotein 1 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    462
  • Mass (Da)
    47,895
  • Last updated
    1998-06-01 v1
  • Checksum
    3EAE5FBA4FC6A298
MKFLSSLVVLGLSAQALASPYVDHQATKDQRDVNVFKQVLQDINLDVQKFDQDITQYQGGDPTVLLADSDAIIKTTEEGIQRIGPQPPLSVTEALALVGPVQGVNKLIMKAVDHLIEKKGPLVGGGYGPQVKDSLERQAHAASKLSELVSSKVPSPLAPISKQLSDQVAQALQKGIQAFSISARQATKVKREATKVQRDISAFKKVIQNISLAVNKFNVDIERYVGGDASHLLADGNVLIKATLDGVQSLQNEPPLSSMEALALVGPVQDLSNQILLAIQNLIDKKEPLVQAGFGGKVENNLRQQEEAAQKLSELVSTKVPHELADISRQLSDGIAAGIKKGIDAFAGTGPAPTTSSTPEASTAPAPSTPPQTPEDTLVPATSTPAPGPAPTAPDSSMVWPTSTTASPDVQPTITSSGTSVPAAPTGGNSSPAVPAFTGAASANQVSGAVGLAAGLLAVLAF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias396-429Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF009957
EMBL· GenBank· DDBJ
AAC39367.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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