O42716 · AFLS_ASPPU

Function

function

Transcription coactivator involved in regulation of the aflatoxin biosynthesis gene cluster with aflR (PubMed:11913765, PubMed:12655397, PubMed:15006741, PubMed:15054098, PubMed:23605486).
The ratio of the expression data between aflS:aflR plays a crucial role in the regulation of aflatoxins production (PubMed:23605486).
A high ratio, produced at a range between 17 and 30 degrees Celsius, corresponds with the production profile of aflatoxin G1 biosynthesis (PubMed:23605486).
A low ratio, produced over 30 degrees Celsius, is related to aflatoxin B1 biosynthesis (PubMed:23605486).
AflJ may act in aflR transport to or from the nucleus, thus controlling the availability of aflR for transcriptional activation of aflatoxin biosynthesis cluster genes (PubMed:23342682).
AflJ may also assist in directing endosomes to the cytoplasmic membrane for aflatoxin export (PubMed:23342682).

Features

Showing features for dna binding.

143850100150200250300350400
TypeIDPosition(s)Description
DNA binding95-114H-T-H motif

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendosome
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionmethyltransferase activity
Biological Processpositive regulation of aflatoxin biosynthetic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Aflatoxin cluster transcriptional coactivator aflS
  • Alternative names
    • Aflatoxin biosynthesis protein S

Gene names

    • Name
      aflS
    • Synonyms
      aflJ
    • ORF names
      P875_00052983

Organism names

Accessions

  • Primary accession
    O42716
  • Secondary accessions
    • A0A0F0HZ07

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Leads to significant decrease in the transcript levels of the genes for early (aflC and aflD), middle (aflM) and later (aflP) steps in the aflatoxin biosynthetic pathway (PubMed:12655397).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004383391-438Aflatoxin cluster transcriptional coactivator aflS

Expression

Induction

Expression is positively regulated by the developmental and secondary metabolism regulator veA (PubMed:15294809).
Expression is repressed during Streptomyces-Aspergillus interactions (PubMed:25741015).

Interaction

Subunit

Interacts with aflR (PubMed:12655397, PubMed:15054098, PubMed:23342682).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain65-134HTH iclR-type

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    438
  • Mass (Da)
    47,229
  • Last updated
    2001-03-01 v2
  • Checksum
    AB645C68A789A603
MTLTDLETCAEEIATAARTLARDGHSGGYSAGLPDHLRAVQRTLIANASQVLALASQPADLVRQLALYNQLLACLRWLGEFQVLACIPLDESVPFEDVADIAGVPECRLRRLVRPLFTIGFLCEPSPGHVAHSVLSKQFVTQPALLDAILFMSETLAPSASAMGTQTRRFGASEQAGDSAWNMAVGSDSPFAACLQQRPKVKRQLGAYLSYVSSAIDAGVEDTLTRMNWQNLGMATVVHVGAQSPSLVVALAPQFPSLRFLVQTEAKAESGGHQPCLDNHGIPALKLASIPLHLRARITWGTRLSTATQPVLDAAVYLISIPFPSPQSPAMEITMRVAQALKAHVEVLRNNSDARLILTLPMSSATRSMDAAARAAVSLSDLSLLQLTNGGSLNMGEIRDLLRSRSDGLVVMREVRSPTNAVIAFEIQYRVDNDDNRY

Sequence caution

The sequence KJK60754.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF002660
EMBL· GenBank· DDBJ
AAB94411.2
EMBL· GenBank· DDBJ
Genomic DNA
AY371490
EMBL· GenBank· DDBJ
AAS66019.1
EMBL· GenBank· DDBJ
Genomic DNA
JZEE01000729
EMBL· GenBank· DDBJ
KJK60754.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

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