O42716 · AFLS_ASPPU
- ProteinAflatoxin cluster transcriptional coactivator aflS
- GeneaflS
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids438 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Transcription coactivator involved in regulation of the aflatoxin biosynthesis gene cluster with aflR (PubMed:11913765, PubMed:12655397, PubMed:15006741, PubMed:15054098, PubMed:23605486).
The ratio of the expression data between aflS:aflR plays a crucial role in the regulation of aflatoxins production (PubMed:23605486).
A high ratio, produced at a range between 17 and 30 degrees Celsius, corresponds with the production profile of aflatoxin G1 biosynthesis (PubMed:23605486).
A low ratio, produced over 30 degrees Celsius, is related to aflatoxin B1 biosynthesis (PubMed:23605486).
AflJ may act in aflR transport to or from the nucleus, thus controlling the availability of aflR for transcriptional activation of aflatoxin biosynthesis cluster genes (PubMed:23342682).
AflJ may also assist in directing endosomes to the cytoplasmic membrane for aflatoxin export (PubMed:23342682).
The ratio of the expression data between aflS:aflR plays a crucial role in the regulation of aflatoxins production (PubMed:23605486).
A high ratio, produced at a range between 17 and 30 degrees Celsius, corresponds with the production profile of aflatoxin G1 biosynthesis (PubMed:23605486).
A low ratio, produced over 30 degrees Celsius, is related to aflatoxin B1 biosynthesis (PubMed:23605486).
AflJ may act in aflR transport to or from the nucleus, thus controlling the availability of aflR for transcriptional activation of aflatoxin biosynthesis cluster genes (PubMed:23342682).
AflJ may also assist in directing endosomes to the cytoplasmic membrane for aflatoxin export (PubMed:23342682).
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 95-114 | H-T-H motif | ||||
Sequence: FEDVADIAGVPECRLRRLVR |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endosome | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | methyltransferase activity | |
Biological Process | positive regulation of aflatoxin biosynthetic process |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAflatoxin cluster transcriptional coactivator aflS
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionO42716
- Secondary accessions
Proteomes
Phenotypes & Variants
Disruption phenotype
Leads to significant decrease in the transcript levels of the genes for early (aflC and aflD), middle (aflM) and later (aflP) steps in the aflatoxin biosynthetic pathway (PubMed:12655397).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000438339 | 1-438 | Aflatoxin cluster transcriptional coactivator aflS | |||
Sequence: MTLTDLETCAEEIATAARTLARDGHSGGYSAGLPDHLRAVQRTLIANASQVLALASQPADLVRQLALYNQLLACLRWLGEFQVLACIPLDESVPFEDVADIAGVPECRLRRLVRPLFTIGFLCEPSPGHVAHSVLSKQFVTQPALLDAILFMSETLAPSASAMGTQTRRFGASEQAGDSAWNMAVGSDSPFAACLQQRPKVKRQLGAYLSYVSSAIDAGVEDTLTRMNWQNLGMATVVHVGAQSPSLVVALAPQFPSLRFLVQTEAKAESGGHQPCLDNHGIPALKLASIPLHLRARITWGTRLSTATQPVLDAAVYLISIPFPSPQSPAMEITMRVAQALKAHVEVLRNNSDARLILTLPMSSATRSMDAAARAAVSLSDLSLLQLTNGGSLNMGEIRDLLRSRSDGLVVMREVRSPTNAVIAFEIQYRVDNDDNRY |
Structure
Sequence
- Sequence statusComplete
- Length438
- Mass (Da)47,229
- Last updated2001-03-01 v2
- ChecksumAB645C68A789A603
Sequence caution
Keywords
- Technical term