O42384 · 5H1AB_TAKRU
- Protein5-hydroxytryptamine receptor 1A-beta
- Genehtr1a-B
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids416 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes.
Activity regulation
G-protein coupled receptor activity is regulated by lipids: phosphatidylinositol 4-phosphate increases HTR1A-mediated activity.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 113 | serotonin (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 117 | serotonin (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 339 | 1D-myo-inositol 4-phosphate (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 340 | 1D-myo-inositol 4-phosphate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 346 | 1D-myo-inositol 4-phosphate (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 397 | 1D-myo-inositol 4-phosphate (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 398 | 1D-myo-inositol 4-phosphate (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 399 | 1D-myo-inositol 4-phosphate (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | synapse | |
Molecular Function | dopamine neurotransmitter receptor activity, coupled via Gs | |
Molecular Function | G protein-coupled serotonin receptor activity | |
Biological Process | adenylate cyclase-activating adrenergic receptor signaling pathway | |
Biological Process | adenylate cyclase-inhibiting serotonin receptor signaling pathway | |
Biological Process | regulation of behavior | |
Biological Process | regulation of hormone secretion | |
Biological Process | regulation of vasoconstriction | |
Biological Process | serotonin receptor signaling pathway |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended name5-hydroxytryptamine receptor 1A-beta
- Short names5-HT-1A-beta; 5-HT1A-beta
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Tetraodontiformes > Tetradontoidea > Tetraodontidae > Takifugu
Accessions
- Primary accessionO42384
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-35 | Extracellular | ||||
Sequence: MEGTNNTTGWTHFDSTSNRTSKSFDEEVKLSYQVV | ||||||
Transmembrane | 36-56 | Helical; Name=1 | ||||
Sequence: TSFLLGALILCSIFGNACVVA | ||||||
Topological domain | 57-70 | Cytoplasmic | ||||
Sequence: AIALERSLQNVANY | ||||||
Transmembrane | 71-95 | Helical; Name=2 | ||||
Sequence: LIGSLAVTDLMVSVLVLPMAALYQV | ||||||
Topological domain | 96-104 | Extracellular | ||||
Sequence: LNRWTLGQI | ||||||
Transmembrane | 105-129 | Helical; Name=3 | ||||
Sequence: PCDIFISLDMLCCTSSILHLCVIAL | ||||||
Topological domain | 130-149 | Cytoplasmic | ||||
Sequence: DRYWAITEPIDYMKKRTPRR | ||||||
Transmembrane | 150-171 | Helical; Name=4 | ||||
Sequence: AAVLISVTWLVGFSISIPPMLI | ||||||
Topological domain | 172-195 | Extracellular | ||||
Sequence: MRSQPSSMAEDRANSKQCKITQDP | ||||||
Transmembrane | 196-218 | Helical; Name=5 | ||||
Sequence: WYTIYSTFGAFYIPLTLMLVLYG | ||||||
Topological domain | 219-340 | Cytoplasmic | ||||
Sequence: RIFKAARFRIRRTVRKTEKKKVSDTCLALSPAMFHRKTPGDAHGKSWKRSVEPRPLPNVNGAVKHAGEGESLDIIEVQSNSRCNLPLPNTPGTVPLFENRHEKATETKRKIALARERKTVKT | ||||||
Transmembrane | 341-364 | Helical; Name=6 | ||||
Sequence: LGIIMGTFILCWLPFFIVALVMPF | ||||||
Topological domain | 365-372 | Extracellular | ||||
Sequence: CQESCFMP | ||||||
Transmembrane | 373-397 | Helical; Name=7 | ||||
Sequence: HWLKDVINWLGYSNSLLNPIIYAYF | ||||||
Topological domain | 398-416 | Cytoplasmic | ||||
Sequence: NKDFQSAFKKIIKCHFCRA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000068924 | 1-416 | 5-hydroxytryptamine receptor 1A-beta | |||
Sequence: MEGTNNTTGWTHFDSTSNRTSKSFDEEVKLSYQVVTSFLLGALILCSIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNRWTLGQIPCDIFISLDMLCCTSSILHLCVIALDRYWAITEPIDYMKKRTPRRAAVLISVTWLVGFSISIPPMLIMRSQPSSMAEDRANSKQCKITQDPWYTIYSTFGAFYIPLTLMLVLYGRIFKAARFRIRRTVRKTEKKKVSDTCLALSPAMFHRKTPGDAHGKSWKRSVEPRPLPNVNGAVKHAGEGESLDIIEVQSNSRCNLPLPNTPGTVPLFENRHEKATETKRKIALARERKTVKTLGIIMGTFILCWLPFFIVALVMPFCQESCFMPHWLKDVINWLGYSNSLLNPIIYAYFNKDFQSAFKKIIKCHFCRA | ||||||
Glycosylation | 5 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 6 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 18 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 106↔189 | |||||
Sequence: CDIFISLDMLCCTSSILHLCVIALDRYWAITEPIDYMKKRTPRRAAVLISVTWLVGFSISIPPMLIMRSQPSSMAEDRANSKQC |
Keywords
- PTM
PTM databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 130-132 | DRY motif; important for ligand-induced conformation changes | ||||
Sequence: DRY | ||||||
Motif | 390-394 | NPxxY motif; important for ligand-induced conformation changes and signaling | ||||
Sequence: NPIIY |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length416
- Mass (Da)47,031
- Last updated1998-01-01 v1
- Checksum9B4CC415BEC750FE
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X95937 EMBL· GenBank· DDBJ | CAA65176.1 EMBL· GenBank· DDBJ | Genomic DNA |