O41782 · O41782_9HIV1
- ProteinGag-Pol polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1437 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
Catalytic activity
- Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Cofactor
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 1372-1419 | Integrase-type | ||||
Sequence: FRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSEIKVVPRRKAKIIRD |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGag-Pol polyprotein
- Alternative names
Organism names
- Organism
- Taxonomic lineageViruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Lentivirus
- Virus hosts
Accessions
- Primary accessionO41782
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Lipid-anchor
Host cell membrane ; Lipid-anchor
Membrane ; Lipid-anchor
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for coiled coil, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 94-121 | |||||
Sequence: VASTKEALDKIEEEQAKSKKKAQQATAD | ||||||
Domain | 392-407 | CCHC-type | ||||
Sequence: KCFNCGKEGHTAKNCR | ||||||
Domain | 414-429 | CCHC-type | ||||
Sequence: CWKCGREGHQMKDCTE | ||||||
Region | 447-483 | Disordered | ||||
Sequence: REFPSEQTPSRANSPTSRDLRIRGGDNTSSETGAERQ | ||||||
Compositional bias | 449-483 | Polar residues | ||||
Sequence: FPSEQTPSRANSPTSRDLRIRGGDNTSSETGAERQ | ||||||
Domain | 510-579 | Peptidase A2 | ||||
Sequence: KEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYDQIPLEICGHKAIGTVLVGPTPVNIIGRNL | ||||||
Domain | 633-823 | Reverse transcriptase | ||||
Sequence: EGKISKIGPENPYNTPIFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLHEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMIIYQYMDDLYVGSDLEIGQHRIKIEELRGHLLKWGFTTPDKKYQKEPPFLWMGYEL | ||||||
Domain | 1023-1146 | RNase H type-1 | ||||
Sequence: IVGAETFYVDGAANRETKIGKAGYVTDRGRQKVVSLTDTTNQKTELQAINLALQDSGLEVNIVTDSQYALGIIQAQPDKSESEVVSQIIEQLIKKEKVYLSWVPAHKGIGGNEQVDKLVSNGIR | ||||||
Domain | 1152-1193 | Integrase-type | ||||
Sequence: DGIDKAQEEHEKYHNNWRAMASEFNLPPVVAKEIVASCDKCQ | ||||||
Domain | 1203-1353 | Integrase catalytic | ||||
Sequence: VDCSPGIWQLDCTHLEGKGILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSNFTSAAVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIIDII | ||||||
Domain | 1372-1419 | Integrase-type | ||||
Sequence: FRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSEIKVVPRRKAKIIRD |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,437
- Mass (Da)162,160
- Last updated1998-01-01 v1
- Checksum2E6DE458EF44C7D3
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 449-483 | Polar residues | ||||
Sequence: FPSEQTPSRANSPTSRDLRIRGGDNTSSETGAERQ |
Keywords
- Coding sequence diversity