O41782 · O41782_9HIV1

Function

Catalytic activity

  • 3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.
    EC:3.1.13.2 (UniProtKB | ENZYME | Rhea)
  • Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
    EC:3.1.26.13 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for dna binding.

114372004006008001,0001,2001,400
TypeIDPosition(s)Description
DNA binding1372-1419Integrase-type

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus
Cellular Componenthost cell plasma membrane
Cellular Componentplasma membrane
Cellular Componentviral nucleocapsid
Molecular Functionaspartic-type endopeptidase activity
Molecular FunctionDNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionexoribonuclease H activity
Molecular FunctionRNA stem-loop binding
Molecular FunctionRNA-directed DNA polymerase activity
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Molecular Functionstructural molecule activity
Molecular Functionzinc ion binding
Biological ProcessDNA integration
Biological ProcessDNA recombination
Biological Processestablishment of integrated proviral latency
Biological Processproteolysis
Biological Processsymbiont entry into host cell
Biological Processsymbiont-mediated suppression of host gene expression
Biological Processviral genome integration into host DNA
Biological Processviral penetration into host nucleus
Biological Processviral translational frameshifting

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Gag-Pol polyprotein
  • Alternative names
    • Pr160Gag-Pol

Organism names

Accessions

  • Primary accession
    O41782

Proteomes

Subcellular Location

Cell membrane
; Lipid-anchor
Cytoplasm
Host cell membrane
; Lipid-anchor
Host cytoplasm
Host nucleus
Membrane
; Lipid-anchor
Virion

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for coiled coil, domain, region, compositional bias.

TypeIDPosition(s)Description
Coiled coil94-121
Domain392-407CCHC-type
Domain414-429CCHC-type
Region447-483Disordered
Compositional bias449-483Polar residues
Domain510-579Peptidase A2
Domain633-823Reverse transcriptase
Domain1023-1146RNase H type-1
Domain1152-1193Integrase-type
Domain1203-1353Integrase catalytic
Domain1372-1419Integrase-type

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,437
  • Mass (Da)
    162,160
  • Last updated
    1998-01-01 v1
  • Checksum
    2E6DE458EF44C7D3
MGARASVLSGGKLDEWEKIRLRPGGKKKYRLKHLVWASRELERFALNPGLLETSEGCRQIIRQLQPSIQTGSEEIKSLYNTVVTLYCVHERIKVASTKEALDKIEEEQAKSKKKAQQATADTRNSSQVSQNYPIVQNLQGQMVHHPLSPRTLNAWVKVIEEKAFNPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKDTINEEAAEWDRLHPVHAGPVAPGQLREPRGSDIAGTTSNLQEQIGWMTSNPPIPVGEIYKRWIILGLNKIVRMYSPVSILDIRQGPKEPFRDYVDRFYKTLRAEQASQDVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTACQGVGGPSHKARVLAEAMSQATNANTAIMMQRGNFKGPKKIIKCFNCGKEGHTAKNCRAPRKKGCWKCGREGHQMKDCTERQANFFRENLAFPQWKAREFPSEQTPSRANSPTSRDLRIRGGDNTSSETGAERQGTVSFNLPQITLWQRPVVTVKIGGQLKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYDQIPLEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNFPISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICSELEKEGKISKIGPENPYNTPIFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLHEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMIIYQYMDDLYVGSDLEIGQHRIKIEELRGHLLKWGFTTPDKKYQKEPPFLWMGYELHPDKWTVQPIHLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKCLRGAKALTEVIPLTAEAELELAENREILKEPVHGAYYDPSKDLIAEIQKQGQDQWTYQIYQEQYKNLKTGKYAKMRGTHTNDVKQLTEAVQKIAQECIVIWGKTPKFRLPIQKETWETWWTEYWQATWIPEWEYVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKIGKAGYVTDRGRQKVVSLTDTTNQKTELQAINLALQDSGLEVNIVTDSQYALGIIQAQPDKSESEVVSQIIEQLIKKEKVYLSWVPAHKGIGGNEQVDKLVSNGIRKILFLDGIDKAQEEHEKYHNNWRAMASEFNLPPVVAKEIVASCDKCQVKGEALHGQVDCSPGIWQLDCTHLEGKGILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKVVHTDNGSNFTSAAVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSEIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias449-483Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U88824
EMBL· GenBank· DDBJ
AAC97575.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp