O35800 · HIF1A_RAT
- ProteinHypoxia-inducible factor 1-alpha
- GeneHif1a
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids825 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Publications for O35800
Ultrasound-targeted microbubble destruction facilitates cartilage repair through increased the migration of mesenchymal stem cells via HIF-1alpha- mediated glycolysis pathway in rats.
- AnnotationUltrasound-targeted microbubble destruction facilitates cartilage repair through increased the migration of mesenchymal stem cells via HIF-1alpha-mediated glycolysis pathway in rats.
- SourceGeneRif: 29560
Aerobic exercise-induced HIF-1alpha upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation.
- AnnotationAerobic exercise-induced HIF-1alpha upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation.
- SourceGeneRif: 29560
Mapped toHypoxia-inducible factor-1alpha attenuates renal podocyte injury in male rats in a simulated high-altitude environment by upregulating Kruppel-like factor 4 expression.
- AnnotationHypoxia-inducible factor-1alpha attenuates renal podocyte injury in male rats in a simulated high-altitude environment by upregulating Kruppel-like factor 4 expression.
- SourceGeneRif: 29560
Lipid nephrotoxicity mediated by HIF-1alpha activation accelerates tubular injury in diabetic nephropathy.
- AnnotationLipid nephrotoxicity mediated by HIF-1alpha activation accelerates tubular injury in diabetic nephropathy.
- SourceGeneRif: 29560
Activation of BMP4/SMAD pathway by HIF-1alpha in hypoxic environment promotes osteogenic differentiation of BMSCs and leads to ectopic bone formation.
- AnnotationActivation of BMP4/SMAD pathway by HIF-1alpha in hypoxic environment promotes osteogenic differentiation of BMSCs and leads to ectopic bone formation.
- SourceGeneRif: 29560
Overexpression of RAD54L attenuates osteoarthritis by suppressing the HIF- 1alpha/VEGF signaling pathway: Bioinformatics analysis and experimental validation.
- AnnotationOverexpression of RAD54L attenuates osteoarthritis by suppressing the HIF-1alpha/VEGF signaling pathway: Bioinformatics analysis and experimental validation.
- SourceGeneRif: 29560
Mitophagy mediated by HIF-1alpha/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury.
- AnnotationMitophagy mediated by HIF-1alpha/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury.
- SourceGeneRif: 29560
Role of HIF-1alpha in hypercoagulable state of COPD in rats.
- AnnotationRole of HIF-1alpha in hypercoagulable state of COPD in rats.
- SourceGeneRif: 29560
Expression of the HIF-1alpha/VEGF pathway is upregulated to protect alveolar bone density reduction in nasal-obstructed rats.
- AnnotationExpression of the HIF-1alpha/VEGF pathway is upregulated to protect alveolar bone density reduction in nasal-obstructed rats.
- SourceGeneRif: 29560
The promotion of sestrin2/AMPK signaling by HIF-1alpha overexpression enhances the damage caused by acute myocardial infarction.
- AnnotationThe promotion of sestrin2/AMPK signaling by HIF-1alpha overexpression enhances the damage caused by acute myocardial infarction.
- SourceGeneRif: 29560
P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia.
- AnnotationP300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia.
- CategoriesFunction
- SourceGeneRif: 29560
The interplay between H19 and HIF-1alpha in mitochondrial dysfunction in myocardial infarction.
- AnnotationThe interplay between H19 and HIF-1alpha in mitochondrial dysfunction in myocardial infarction.
- CategoriesFunction
- SourceGeneRif: 29560
HIF-1A regulates cognitive deficits of post-stroke depressive rats.
- AnnotationHIF-1A regulates cognitive deficits of post-stroke depressive rats.
- CategoriesFunction
- SourceGeneRif: 29560
HIF-1alpha-PPARgamma-mTORC1 signaling pathway-mediated autophagy induces inflammatory response in pancreatic cells in rats with hyperlipidemic acute pancreatitis.
- AnnotationHIF-1alpha-PPARgamma-mTORC1 signaling pathway-mediated autophagy induces inflammatory response in pancreatic cells in rats with hyperlipidemic acute pancreatitis.
- CategoriesFunction
- SourceGeneRif: 29560
CREB-binding protein and HIF-1alpha/beta-catenin to upregulate miR-322 and alleviate myocardial ischemia-reperfusion injury.
- AnnotationCREB-binding protein and HIF-1alpha/beta-catenin to upregulate miR-322 and alleviate myocardial ischemia-reperfusion injury.
- CategoriesFunction
- SourceGeneRif: 29560
HIF-1alpha/MMP-9 promotes spinal cord central sensitization in rats with bone cancer pain.
- AnnotationHIF-1alpha/MMP-9 promotes spinal cord central sensitization in rats with bone cancer pain.
- CategoriesFunction
- SourceGeneRif: 29560
Autologous blood transfusion promotes autophagy and inhibits hepatocellular carcinoma progression through HIF-1alpha signalling pathway.
- AnnotationAutologous blood transfusion promotes autophagy and inhibits hepatocellular carcinoma progression through HIF-1alpha signalling pathway.
- CategoriesFunction
- SourceGeneRif: 29560
Hypermethylation of the Bmp4 promoter dampens binding of HIF-1alpha and impairs its cardiac protective effects from oxidative stress in prenatally GC-exposed offspring.
- AnnotationHypermethylation of the Bmp4 promoter dampens binding of HIF-1alpha and impairs its cardiac protective effects from oxidative stress in prenatally GC-exposed offspring.
- CategoriesFunction
- SourceGeneRif: 29560
Oxygen-generating microparticles downregulate HIF-1alpha expression, increase cardiac contractility, and mitigate ischemic injury.
- AnnotationOxygen-generating microparticles downregulate HIF-1alpha expression increase cardiac contractility and mitigate ischemic injury.
- CategoriesFunction
- SourceGeneRif: 29560
HIF-1alpha Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia.
- AnnotationHIF-1alpha Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia.
- CategoriesFunction
- SourceGeneRif: 29560
HIF‑1alpha protects PC12 cells from OGD/R‑induced cell injury by regulating autophagy flux through the miR‑20a‑5p/KIF5A axis.
- AnnotationHIF1alpha protects PC12 cells from OGD/Rinduced cell injury by regulating autophagy flux through the miR20a5p/KIF5A axis.
- CategoriesFunction
- SourceGeneRif: 29560
Roles of HIF-1alpha/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.
- AnnotationRoles of HIF-1alpha/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.
- CategoriesFunction
- SourceGeneRif: 29560