HIF-1alpha plays a central role in bone marrow-derived endothelial progenitor cell (bmEPC) homing and sprouting in the post-acute stage of ischemic Sprague Dawley (SD) rat brains.
Hypoxia might be an etiological factor for femoral head necrosis HIF-1alpha with VEGF as well as apoptotic genes participating the pathophysiological process of ischemic osteonecrosis.
Results demonstrate that HIF-1alpha induced by ischemia in early and late times leads cellular apoptosis and survival respectively and provides a new insight into the divergent roles of HIF-1alpha expression in neurons after ischemic stroke.
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