O35740 · CITE2_MOUSE

  • Protein
    Cbp/p300-interacting transactivator 2
  • Gene
    Cited2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular Functionhistone acetyltransferase binding
Molecular FunctionLBD domain binding
Molecular FunctionRNA polymerase II-specific DNA-binding transcription factor binding
Molecular FunctionSMAD binding
Molecular Functiontranscription coactivator activity
Molecular Functiontranscription coregulator activity
Molecular Functiontranscription corepressor activity
Biological Processadrenal cortex formation
Biological Processadrenal gland development
Biological Processblood vessel development
Biological Processbone morphogenesis
Biological Processcardiac neural crest cell development involved in heart development
Biological Processcardiac septum morphogenesis
Biological Processcell population proliferation
Biological Processcellular response to hypoxia
Biological Processcellular senescence
Biological Processcentral nervous system development
Biological Processcranial nerve morphogenesis
Biological Processdecidualization
Biological Processdetermination of heart left/right asymmetry
Biological Processdetermination of left/right asymmetry in lateral mesoderm
Biological Processdetermination of left/right symmetry
Biological Processembryonic camera-type eye morphogenesis
Biological Processembryonic heart tube left/right pattern formation
Biological Processembryonic placenta development
Biological Processembryonic process involved in female pregnancy
Biological Processendocardial cushion development
Biological Processerythrocyte development
Biological Processgranulocyte differentiation
Biological Processheart development
Biological Processheart looping
Biological Processhematopoietic progenitor cell differentiation
Biological Processin utero embryonic development
Biological Processleft/right axis specification
Biological Processleft/right pattern formation
Biological Processlens morphogenesis in camera-type eye
Biological Processleukocyte differentiation
Biological Processliver development
Biological Processmale gonad development
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of cardiac muscle cell proliferation
Biological Processnegative regulation of cell migration
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of gene expression
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processneural tube closure
Biological Processneural tube formation
Biological Processnodal signaling pathway
Biological Processoutflow tract morphogenesis
Biological Processperipheral nervous system development
Biological Processpositive regulation of cell cycle
Biological Processpositive regulation of cell-cell adhesion
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of male gonad development
Biological Processpositive regulation of peroxisome proliferator activated receptor signaling pathway
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of transforming growth factor beta receptor signaling pathway
Biological Processpulmonary artery morphogenesis
Biological Processregulation of animal organ formation
Biological Processregulation of DNA-templated transcription
Biological Processregulation of transcription by RNA polymerase II
Biological Processresponse to estrogen
Biological Processresponse to fluid shear stress
Biological Processresponse to hypoxia
Biological Processresponse to mechanical stimulus
Biological Processsex determination
Biological Processskeletal muscle cell differentiation
Biological Processspleen development
Biological Processthymus development
Biological Processtransforming growth factor beta receptor signaling pathway
Biological Processtrophectodermal cell differentiation
Biological Processuterus development
Biological Processvasculature development
Biological Processvasculogenesis
Biological Processventricular septum development
Biological Processventricular septum morphogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cbp/p300-interacting transactivator 2
  • Alternative names
    • MSG-related protein 1 (MRG-1)
    • P35srj

Gene names

    • Name
      Cited2
    • Synonyms
      Mrg1, Msg2

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6 X DBA
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O35740
  • Secondary accessions
    • O35741
    • O35742
    • O35743
    • O55198
    • Q6PGA9

Proteomes

Organism-specific databases

Subcellular Location

Note: Colocalizes with EP300 in dot-like structures.

Keywords

Phenotypes & Variants

Disruption phenotype

Mice embryos die during gestation with left-right patterning defects and severe developmental abnormalities, including cardiac malformations, exencephaly and adrenal agenesis. Show also impaired mesonephric tubules and adrenal cortex development in embryos.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 5 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001447271-269Cbp/p300-interacting transactivator 2

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitous.

Developmental stage

Expressed in the embryonic heart. Expressed in the ventral node, cardiac crescent and blood islands at 7.5 dpc. Expressed in the cardiac crescent, anterior lateral mesoderm and in trunk paraxial mesoderm at 8 dpc. Expressed in forebrain-midbrain boundary, branchial arches 1 and 2, heart and somites at 9.5 dpc (at protein level). Expressed in the coelomic epithelium and in cells in the underlying nephrogenic mesenchyme of the genital ridge at 10 dpc. Expressed in the genital ridge and the presumptive adrenal area at 10.5 dpc. Expressed in the gonad and in the adrenal anlagen at 12 dpc. Expressed in the cells of the adrenal cortex at 14 dpc. Expressed throughout the embryonic heart, as well as in the node and the lateral plate mesoderm (LPM), that are responsible for initiating and maintaining left-right patterning. Expressed in the crown cells of the node.

Gene expression databases

Interaction

Subunit

Interacts (via C-terminus) with EP300 (via CH1 domain); the interaction is stimulated in response to hypoxia. Interacts with PPARA. Interacts (via C-terminus) with TFAP2A, TFAP2B and TFAP2C (By similarity).
Interacts (via C-terminus) with SMAD2. Interacts (via C-terminus) with SMAD3 (via MH2 domain). Interacts with LHX2 (via LIM domains). Interacts with WT1 isoform 1 and isoform 3.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region142-200Disordered
Compositional bias143-197Polar residues

Sequence similarities

Belongs to the CITED family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

O35740-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    269
  • Mass (Da)
    28,321
  • Last updated
    2012-10-03 v2
  • Checksum
    0FFCD8C21E4E3D81
MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEHIHYGAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQKLNNQYFNHHPYPHNHYMPDLHPTAGHQMNGTNQHFRDCNPKHSGGSSTPGGAGGSGTPGGSGGTSGGAGGSSAGGSGGGSTMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGLDRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC

O35740-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

O35740-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

O35740-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1W2P7B1A0A1W2P7B1_MOUSECited29

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_001090138-158in isoform 2
Compositional bias143-197Polar residues
Alternative sequenceVSP_001091159-213in isoform 3
Sequence conflict194-195in Ref. 1; CAA75432/CAA75435
Alternative sequenceVSP_001092203-213in isoform 4

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y15163
EMBL· GenBank· DDBJ
CAA75432.1
EMBL· GenBank· DDBJ
mRNA
Y15163
EMBL· GenBank· DDBJ
CAA75433.1
EMBL· GenBank· DDBJ
mRNA
Y15163
EMBL· GenBank· DDBJ
CAA75434.1
EMBL· GenBank· DDBJ
mRNA
Y15163
EMBL· GenBank· DDBJ
CAA75435.1
EMBL· GenBank· DDBJ
mRNA
U86445
EMBL· GenBank· DDBJ
AAC39945.1
EMBL· GenBank· DDBJ
mRNA
AK131664
EMBL· GenBank· DDBJ
BAE20751.1
EMBL· GenBank· DDBJ
mRNA
AK133791
EMBL· GenBank· DDBJ
BAE21844.1
EMBL· GenBank· DDBJ
mRNA
AC105167
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466562
EMBL· GenBank· DDBJ
EDL03481.1
EMBL· GenBank· DDBJ
Genomic DNA
BC057126
EMBL· GenBank· DDBJ
AAH57126.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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