O35607 · BMPR2_MOUSE
- ProteinBone morphogenetic protein receptor type-2
- GeneBmpr2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1038 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (By similarity).
Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6 (PubMed:23527555).
Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6 (PubMed:23527555).
Catalytic activity
- ATP + L-threonyl-[receptor-protein] = ADP + H+ + O-phospho-L-threonyl-[receptor-protein]
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 209-217 | ATP (UniProtKB | ChEBI) | ||||
Sequence: IGRGRYGAV | ||||||
Binding site | 230 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 280-282 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EYY | ||||||
Active site | 333 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 337-338 | ATP (UniProtKB | ChEBI) | ||||
Sequence: RN | ||||||
Binding site | 351 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBone morphogenetic protein receptor type-2
- EC number
- Short namesBMP type-2 receptor; BMPR-2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionO35607
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 27-150 | Extracellular | ||||
Sequence: SQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDET | ||||||
Transmembrane | 151-171 | Helical | ||||
Sequence: IIIALASVSVLAVLIVALCFG | ||||||
Topological domain | 172-1038 | Cytoplasmic | ||||
Sequence: YRMLTGDRKQGLHSMNMMEAAAAEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERLTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGACVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEVFMRCTDLFPGESVPDYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETHLHATNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQDFTQAANGQACLIPDVPPAQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGNKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRSHNVNSHAATTQYANGAVPAGQAANIVAHRSQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDILTQGVTSTAADPGPSKPRRAQRPNSLDLSATNILDGSSIQIGESTQDGKSGSGEKIKRRVKTPYSLKRWRPSTWVISTEPLDCEVNNNGSDRAVHSKSSTAVYLAEGGTATTTVSKDIGMNCL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MTSSLHRPFRVPWLLWAVLLVSTTAA | ||||||
Chain | PRO_0000024416 | 27-1038 | Bone morphogenetic protein receptor type-2 | |||
Sequence: SQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAAAEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERLTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGACVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEVFMRCTDLFPGESVPDYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETHLHATNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQDFTQAANGQACLIPDVPPAQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGNKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRSHNVNSHAATTQYANGAVPAGQAANIVAHRSQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDILTQGVTSTAADPGPSKPRRAQRPNSLDLSATNILDGSSIQIGESTQDGKSGSGEKIKRRVKTPYSLKRWRPSTWVISTEPLDCEVNNNGSDRAVHSKSSTAVYLAEGGTATTTVSKDIGMNCL | ||||||
Disulfide bond | 34↔66 | |||||
Sequence: CAFKDPYQQDLGIGESRISHENGTILCSKGSTC | ||||||
Glycosylation | 55 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 60↔84 | |||||
Sequence: CSKGSTCYGLWEKSKGDINLVKQGC | ||||||
Disulfide bond | 94↔117 | |||||
Sequence: CHYEECVVTTTPPSIQNGTYRFCC | ||||||
Disulfide bond | 99↔116 | |||||
Sequence: CVVTTTPPSIQNGTYRFC | ||||||
Glycosylation | 110 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 118↔123 | |||||
Sequence: CSTDLC | ||||||
Glycosylation | 126 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Modified residue | 379 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 586 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 680 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 681 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 843 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with GDF5 (By similarity).
Interacts with BMP4 (By similarity).
Interacts with SCUBE3 (By similarity).
Interacts with TSC22D1/TSC-22 (By similarity).
Interacts with BMP4 (By similarity).
Interacts with SCUBE3 (By similarity).
Interacts with TSC22D1/TSC-22 (By similarity).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O35607 | Prkg1 P0C605 | 4 | EBI-527224, EBI-6991999 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 203-504 | Protein kinase | ||||
Sequence: LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERLTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGACVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEVFMRCTDLFPGESVPDYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAEL | ||||||
Region | 593-626 | Disordered | ||||
Sequence: QAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGM | ||||||
Region | 746-769 | Disordered | ||||
Sequence: PKQQNLPKRPTSLPLNTKNSTKEP | ||||||
Compositional bias | 750-768 | Polar residues | ||||
Sequence: NLPKRPTSLPLNTKNSTKE | ||||||
Compositional bias | 872-897 | Basic and acidic residues | ||||
Sequence: RREQQAGHDEGVLDRLVDRRERPLEG | ||||||
Region | 872-974 | Disordered | ||||
Sequence: RREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDILTQGVTSTAADPGPSKPRRAQRPNSLDLSATNILDGSSIQIGESTQDGKSGSGEKIKRR | ||||||
Compositional bias | 898-925 | Polar residues | ||||
Sequence: GRTNSNNNNSNPCSEQDILTQGVTSTAA | ||||||
Compositional bias | 937-964 | Polar residues | ||||
Sequence: RPNSLDLSATNILDGSSIQIGESTQDGK |
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length1,038
- Mass (Da)115,020
- Last updated1998-01-01 v1
- Checksum4106945DC63250E1
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 750-768 | Polar residues | ||||
Sequence: NLPKRPTSLPLNTKNSTKE | ||||||
Compositional bias | 872-897 | Basic and acidic residues | ||||
Sequence: RREQQAGHDEGVLDRLVDRRERPLEG | ||||||
Compositional bias | 898-925 | Polar residues | ||||
Sequence: GRTNSNNNNSNPCSEQDILTQGVTSTAA | ||||||
Compositional bias | 937-964 | Polar residues | ||||
Sequence: RPNSLDLSATNILDGSSIQIGESTQDGK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF003942 EMBL· GenBank· DDBJ | AAB63042.1 EMBL· GenBank· DDBJ | mRNA | ||
U78048 EMBL· GenBank· DDBJ | AAB87638.1 EMBL· GenBank· DDBJ | mRNA |