O35568 · FBLN3_RAT
- ProteinEGF-containing fibulin-like extracellular matrix protein 1
- GeneEfemp1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids493 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | basement membrane | |
Cellular Component | extracellular space | |
Molecular Function | calcium ion binding | |
Molecular Function | epidermal growth factor receptor activity | |
Molecular Function | epidermal growth factor receptor binding | |
Molecular Function | growth factor activity | |
Biological Process | camera-type eye development | |
Biological Process | embryonic eye morphogenesis | |
Biological Process | epidermal growth factor receptor signaling pathway | |
Biological Process | negative regulation of chondrocyte differentiation | |
Biological Process | negative regulation of neuron projection development | |
Biological Process | peptidyl-tyrosine phosphorylation | |
Biological Process | positive regulation of cell population proliferation | |
Biological Process | positive regulation of cell projection organization | |
Biological Process | post-embryonic eye morphogenesis | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | regulation of glial cell migration |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameEGF-containing fibulin-like extracellular matrix protein 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionO35568
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes to the lamina propria underneath the olfactory epithelium.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-17 | |||||
Sequence: MLQTVFLTMLTLALVKS | ||||||
Chain | PRO_0000007573 | 18-493 | EGF-containing fibulin-like extracellular matrix protein 1 | |||
Sequence: QVTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETPAAEASSGAATGTIAARSMATSGVIPGGGFIASATAVAGPEVQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTSGTHNCRLDQVCINLRGSFTCHCLPGYQKRGEQCVDIDECSVPPYCHQGCVNTPGSFYCQCNPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPQNPCQDPYVLTSENRCVCPVSNTMCRDVPQSIVYKYMNIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLTGPREHIVGLEMLTVSSIGTFRTSSVLRLTIIVGPFSF | ||||||
Disulfide bond | 177↔190 | |||||
Sequence: CTSGTHNCRLDQVC | ||||||
Disulfide bond | 184↔199 | |||||
Sequence: CRLDQVCINLRGSFTC | ||||||
Disulfide bond | 201↔212 | |||||
Sequence: CLPGYQKRGEQC | ||||||
Disulfide bond | 218↔228 | |||||
Sequence: CSVPPYCHQGC | ||||||
Disulfide bond | 224↔237 | |||||
Sequence: CHQGCVNTPGSFYC | ||||||
Disulfide bond | 239↔252 | |||||
Sequence: CNPGFQLAANNYTC | ||||||
Glycosylation | 249 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 258↔268 | |||||
Sequence: CDASNQCAQQC | ||||||
Disulfide bond | 264↔277 | |||||
Sequence: CAQQCYNILGSFIC | ||||||
Disulfide bond | 279↔292 | |||||
Sequence: CNQGYELSSDRLNC | ||||||
Disulfide bond | 298↔309 | |||||
Sequence: CRTSSYLCQYQC | ||||||
Disulfide bond | 305↔318 | |||||
Sequence: CQYQCVNEPGKFSC | ||||||
Disulfide bond | 320↔332 | |||||
Sequence: CPQGYQVVRSRTC | ||||||
Disulfide bond | 338↔350 | |||||
Sequence: CETTNECREDEMC | ||||||
Disulfide bond | 344↔359 | |||||
Sequence: CREDEMCWNYHGGFRC | ||||||
Disulfide bond | 365↔377 | |||||
Sequence: CQDPYVLTSENRC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed by olfactory ensheathing cells (at protein level). Detected in lung, intestine and kidney.
Interaction
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-71 | EGF-like 1; atypical | ||||
Sequence: YTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCL | ||||||
Domain | 173-213 | EGF-like 2; calcium-binding | ||||
Sequence: DIDECTSGTHNCRLDQVCINLRGSFTCHCLPGYQKRGEQCV | ||||||
Domain | 214-253 | EGF-like 3; calcium-binding | ||||
Sequence: DIDECSVPPYCHQGCVNTPGSFYCQCNPGFQLAANNYTCV | ||||||
Domain | 254-293 | EGF-like 4; calcium-binding | ||||
Sequence: DINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCE | ||||||
Region | 259-493 | Mediates interaction with TIMP3 | ||||
Sequence: DASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPQNPCQDPYVLTSENRCVCPVSNTMCRDVPQSIVYKYMNIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLTGPREHIVGLEMLTVSSIGTFRTSSVLRLTIIVGPFSF | ||||||
Domain | 294-333 | EGF-like 5; calcium-binding | ||||
Sequence: DIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQ | ||||||
Domain | 334-378 | EGF-like 6; calcium-binding | ||||
Sequence: DINECETTNECREDEMCWNYHGGFRCYPQNPCQDPYVLTSENRCV |
Sequence similarities
Belongs to the fibulin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length493
- Mass (Da)54,596
- Last updated1998-01-01 v1
- Checksum22DAFD70BACF1CA5
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6A7G5 | A0A8I6A7G5_RAT | Efemp1 | 500 | ||
A0A8I6A1M7 | A0A8I6A1M7_RAT | Efemp1 | 507 | ||
Q6AXN2 | Q6AXN2_RAT | Efemp1 | 493 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D89730 EMBL· GenBank· DDBJ | BAA22265.1 EMBL· GenBank· DDBJ | mRNA |