Deficiency for the histone methyltransferase EHMT2 or for the Polycomb group protein EED leads to biallelic expression of Tfpi2 in the extra-embryonic lineages whereas the other genes in the cluster maintain correct imprinting.
Our data suggest that TFPI-2 may be an important regulator of aberrant angiogenesis associated with tumor growth/metastasis cardiovascular diseases chronic inflammation or diabetes.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.