O35437 · TCF21_MOUSE

  • Protein
    Transcription factor 21
  • Gene
    Tcf21
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May be involved in the organogenesis of the spleen and heart and in cardiac and coronary artery development. May function in the development and sex differentiation of gonad via transcriptional regulation of AD4BP/SF-1.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componenttranscription regulator complex
Molecular FunctionbHLH transcription factor binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular FunctionE-box binding
Molecular Functionhistone deacetylase binding
Molecular Functionnuclear androgen receptor binding
Molecular Functionprotein dimerization activity
Biological Processanimal organ morphogenesis
Biological Processbranching involved in ureteric bud morphogenesis
Biological Processbranchiomeric skeletal muscle development
Biological Processbronchiole development
Biological Processdiaphragm development
Biological Processembryonic digestive tract morphogenesis
Biological Processepithelial cell differentiation
Biological Processgland development
Biological Processglomerulus development
Biological Processkidney development
Biological Processlung alveolus development
Biological Processlung morphogenesis
Biological Processlung vasculature development
Biological Processmetanephric glomerular capillary formation
Biological Processmetanephric mesenchymal cell differentiation
Biological Processmorphogenesis of a branching structure
Biological Processnegative regulation of androgen receptor signaling pathway
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processreproductive structure development
Biological Processrespiratory system development
Biological Processroof of mouth development
Biological ProcessSertoli cell differentiation
Biological Processsex determination
Biological Processsex differentiation
Biological Processspleen development
Biological Processureteric bud development
Biological Processvasculature development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcription factor 21
  • Short names
    TCF-21
  • Alternative names
    • Capsulin
    • Epicardin
    • Podocyte-expressed 1 (Pod-1)

Gene names

    • Name
      Tcf21
    • Synonyms
      Pod1

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • 129/Sv
    • C57BL/6J
    • NOD
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O35437
  • Secondary accessions
    • Q3U023

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001274651-179Transcription factor 21

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed at high levels in lung, kidney, gut, heart, ovary and podocytes (visceral glomerular epithelial cells). Also found in spleen, large intestine, uterus, bladder and testis.

Developmental stage

Expressed during embryogenesis specifically in mesodermally-derived cells that surround the epithelium of the developing gastrointestinal, genitourinary, respiratory systems and in spiral septum of the heart and in epicardial precursor cells fated to form the coronary arteries. Expression pattern is sex- and stage-dependent during gonadogenesis. At 13.5 dpc expressed at higher levels in testis than ovary. In 3-month old adults expression drastically decreased in testis while it increased in ovary showing an opposite sex-dependent pattern in adults compared with fetuses. Expression in other organs was similar between the adults and the fetal stage.

Gene expression databases

Interaction

Subunit

Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 and binds the E box (5'-CANNTG-3').

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region19-88Disordered
Compositional bias27-49Polar residues
Compositional bias67-81Polar residues
Domain79-131bHLH

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    179
  • Mass (Da)
    19,681
  • Last updated
    1998-01-01 v1
  • Checksum
    7BA3892818DB355F
MSTGSLSDVEDLQEVEMLDCDSLKVDSNKEFGTSNESTEEGSNCENGSPQKGRGGLGKRRKAPTKKSPLSGVSQEGKQVQRNAANARERARMRVLSKAFSRLKTTLPWVPPDTKLSKLDTLRLASSYIAHLRQILANDKYENGYIHPVNLTWPFMVAGKPENDLKEVVTANRLCGTTAS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1W2P7S0A0A1W2P7S0_MOUSETcf21169

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias27-49Polar residues
Compositional bias67-81Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF029753
EMBL· GenBank· DDBJ
AAB84256.1
EMBL· GenBank· DDBJ
mRNA
AF047418
EMBL· GenBank· DDBJ
AAC62531.1
EMBL· GenBank· DDBJ
mRNA
AF036945
EMBL· GenBank· DDBJ
AAC23537.1
EMBL· GenBank· DDBJ
mRNA
AF035717
EMBL· GenBank· DDBJ
AAC62513.1
EMBL· GenBank· DDBJ
mRNA
AB009453
EMBL· GenBank· DDBJ
BAA23883.1
EMBL· GenBank· DDBJ
mRNA
AK011575
EMBL· GenBank· DDBJ
BAB27709.1
EMBL· GenBank· DDBJ
mRNA
AK135423
EMBL· GenBank· DDBJ
BAE22527.1
EMBL· GenBank· DDBJ
mRNA
AK157289
EMBL· GenBank· DDBJ
BAE34032.1
EMBL· GenBank· DDBJ
mRNA
BC053525
EMBL· GenBank· DDBJ
AAH53525.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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