O35308 · MOT3_MOUSE

  • Protein
    Monocarboxylate transporter 3
  • Gene
    Slc16a8
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (By similarity).
May facilitate transport of lactate and H+ out of the retina and could therefore play an essential role in maintenance of metabolic and ionic homeostasis of the outer retina (PubMed:18524945).

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbasal plasma membrane
Cellular Componentbasolateral plasma membrane
Cellular Componentplasma membrane
Molecular Functionlactate transmembrane transporter activity
Molecular Functionmonocarboxylic acid transmembrane transporter activity
Molecular Functionsymporter activity
Biological Processmonocarboxylic acid transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Monocarboxylate transporter 3
  • Short names
    MCT 3
  • Alternative names
    • Proton-coupled monocarboxylate transporter 3
    • Solute carrier family 16 member 8

Gene names

    • Name
      Slc16a8
    • Synonyms
      Mct3

Organism names

  • Taxonomic identifier
  • Strains
    • 129/Sv
    • C3H/HeJ
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O35308

Proteomes

Organism-specific databases

Subcellular Location

Basolateral cell membrane
; Multi-pass membrane protein
Note: Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression (By similarity).
Colocalizes with BSG in basolateral cell membrane of the retinal pigment epithelium (PubMed:18524945).

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-14Cytoplasmic
Transmembrane15-35Helical
Topological domain36-58Extracellular
Transmembrane59-79Helical
Topological domain80-85Cytoplasmic
Transmembrane86-106Helical
Topological domain107-115Extracellular
Transmembrane116-136Helical
Topological domain137-146Cytoplasmic
Transmembrane147-167Helical
Topological domain168-172Extracellular
Transmembrane173-193Helical
Topological domain194-228Cytoplasmic
Transmembrane229-249Helical
Topological domain250-257Extracellular
Transmembrane258-278Helical
Topological domain279-293Cytoplasmic
Transmembrane294-314Helical
Topological domain315-318Extracellular
Transmembrane319-339Helical
Topological domain340-352Cytoplasmic
Transmembrane353-373Helical
Topological domain374-386Extracellular
Transmembrane387-407Helical
Topological domain408-492Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Deficient mice exhibit significant differences in lactate concentration and pH in the retina and display reduced visual function.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 28 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002113911-492Monocarboxylate transporter 3

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed exclusively in retinal pigment epithelium and choroid plexus epithelium.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region419-492Disordered
Region426-460Basolateral sorting signal
Compositional bias427-443Basic and acidic residues
Region461-482Basolateral sorting signal
Compositional bias476-492Basic and acidic residues

Domain

The two basolateral sorting signals (BLSS) in C-terminal cytoplasmic tails direct SLC16A8 to the basolateral membrane.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    492
  • Mass (Da)
    51,556
  • Last updated
    2000-10-01 v2
  • Checksum
    2B19E362B96D9ACC
MGAGGPRRGAGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLVELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSMLSPLGQLLGERFGWRGGFLLFGGLLLHCCACGAVMRPPPGPPPRRDPSPHGGPARRRRLLDVAVCTDRAFVVYVVTKFLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLAGSEVALAGVFMAVTTYCCLRCSKNISSGRSAEGGASDPEDVEAERDSEPMPASTEEPGSLEALEVLSPRAGSPEQEPEEEAVPELDHESIGGHEARGQKA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias427-443Basic and acidic residues
Compositional bias476-492Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF019111
EMBL· GenBank· DDBJ
AAB70582.2
EMBL· GenBank· DDBJ
mRNA
AF178956
EMBL· GenBank· DDBJ
AAF45042.1
EMBL· GenBank· DDBJ
Genomic DNA
BC018216
EMBL· GenBank· DDBJ
AAH18216.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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