O35149 · ZNT4_MOUSE
- ProteinProbable proton-coupled zinc antiporter SLC30A4
- GeneSlc30a4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids430 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Probable proton-coupled zinc ion antiporter mediating zinc import from cytoplasm potentially into the endocytic compartment (PubMed:9354792).
Controls zinc deposition in milk (PubMed:9354792).
Controls zinc deposition in milk (PubMed:9354792).
Catalytic activity
- 2 H+(out) + Zn2+(in) = 2 H+(in) + Zn2+(out)
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 146 | Zn2+ (UniProtKB | ChEBI); transported zinc | ||||
Sequence: H | ||||||
Binding site | 150 | Zn2+ (UniProtKB | ChEBI); transported zinc | ||||
Sequence: D | ||||||
Binding site | 278 | Zn2+ (UniProtKB | ChEBI); transported zinc | ||||
Sequence: H | ||||||
Binding site | 282 | Zn2+ (UniProtKB | ChEBI); transported zinc | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endosome membrane | |
Cellular Component | late endosome membrane | |
Cellular Component | lysosomal membrane | |
Cellular Component | plasma membrane | |
Molecular Function | antiporter activity | |
Molecular Function | metal ion binding | |
Molecular Function | zinc ion transmembrane transporter activity | |
Biological Process | response to toxic substance | |
Biological Process | response to zinc ion | |
Biological Process | zinc export across plasma membrane | |
Biological Process | zinc ion import into lysosome | |
Biological Process | zinc ion transmembrane transport |
Keywords
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProbable proton-coupled zinc antiporter SLC30A4
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionO35149
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endosome membrane ; Multi-pass membrane protein
Late endosome membrane ; Multi-pass membrane protein
Lysosome membrane ; Multi-pass membrane protein
Note: Enriched in vesicles within the basal region of epithelial cells.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-113 | Cytoplasmic | ||||
Sequence: MAGPGAWKRLKSLLRKDDTPLFLNDTSAFDFSDEVSDEGLSRFNKLRVVVADDDSEAPERPVNGAHPALQADDDSLLDQDLPLTNSQLSLKMDPCDNCSKRRELLKQRKVKTR | ||||||
Transmembrane | 114-134 | Helical | ||||
Sequence: LTIAAVLYLLFMIGELVGGYM | ||||||
Topological domain | 135-143 | Lumenal | ||||
Sequence: ANSLAIMTD | ||||||
Transmembrane | 144-164 | Helical | ||||
Sequence: ALHMLTDLSAIILTLLALWLS | ||||||
Topological domain | 165-178 | Cytoplasmic | ||||
Sequence: SKSPTRRFTFGFHR | ||||||
Transmembrane | 179-199 | Helical | ||||
Sequence: LEVLSAMISVMLVYVLMGFLL | ||||||
Topological domain | 200-216 | Lumenal | ||||
Sequence: YEAVQRTIHMNYEINGD | ||||||
Transmembrane | 217-237 | Helical | ||||
Sequence: VMLITAAVGVAVNVIMGFLLN | ||||||
Topological domain | 238-275 | Cytoplasmic | ||||
Sequence: QSGHHHSHAHSHSLPSNSPSMVSSGHNHGQDSLAVRAA | ||||||
Transmembrane | 276-296 | Helical | ||||
Sequence: FVHALGDLVQSVGVLIAAYII | ||||||
Topological domain | 297-311 | Lumenal | ||||
Sequence: RFKPEYKIADPICTY | ||||||
Transmembrane | 312-332 | Helical | ||||
Sequence: IFSLLVAFTTFRIIWDTVVII | ||||||
Topological domain | 333-430 | Cytoplasmic | ||||
Sequence: LEGVPSHLNVDYIKESLMKIEDVYSVEDLNIWSLTSGKSTAIVHMQLIPGSSSKWEEVQSKAKHLLLNTFGMYKCTIQLQSYRQEVIRTCANCHSSST |
Keywords
- Cellular component
Phenotypes & Variants
Involvement in disease
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000206100 | 1-430 | Probable proton-coupled zinc antiporter SLC30A4 | |||
Sequence: MAGPGAWKRLKSLLRKDDTPLFLNDTSAFDFSDEVSDEGLSRFNKLRVVVADDDSEAPERPVNGAHPALQADDDSLLDQDLPLTNSQLSLKMDPCDNCSKRRELLKQRKVKTRLTIAAVLYLLFMIGELVGGYMANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTRRFTFGFHRLEVLSAMISVMLVYVLMGFLLYEAVQRTIHMNYEINGDVMLITAAVGVAVNVIMGFLLNQSGHHHSHAHSHSLPSNSPSMVSSGHNHGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYIFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKESLMKIEDVYSVEDLNIWSLTSGKSTAIVHMQLIPGSSSKWEEVQSKAKHLLLNTFGMYKCTIQLQSYRQEVIRTCANCHSSST | ||||||
Modified residue | 36 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed. Highly expressed in the brain and in mammary epithelial cell lines.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 240-265 | Zinc binding | ||||
Sequence: GHHHSHAHSHSLPSNSPSMVSSGHNH | ||||||
Region | 245-264 | Disordered | ||||
Sequence: HAHSHSLPSNSPSMVSSGHN | ||||||
Compositional bias | 249-264 | Polar residues | ||||
Sequence: HSLPSNSPSMVSSGHN |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length430
- Mass (Da)47,800
- Last updated2011-07-27 v2
- ChecksumE2311FA6316D15C6
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A2AK40 | A2AK40_MOUSE | Slc30a4 | 381 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 249-264 | Polar residues | ||||
Sequence: HSLPSNSPSMVSSGHN | ||||||
Sequence conflict | 426 | in Ref. 1; AAB82593 | ||||
Sequence: H → Q |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF004099 EMBL· GenBank· DDBJ | AAB82413.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF003747 EMBL· GenBank· DDBJ | AAB82593.1 EMBL· GenBank· DDBJ | mRNA | ||
AF004098 EMBL· GenBank· DDBJ | AAB82412.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF004097 EMBL· GenBank· DDBJ | AAB82411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF004100 EMBL· GenBank· DDBJ | AAB82414.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK134245 EMBL· GenBank· DDBJ | BAE22062.1 EMBL· GenBank· DDBJ | mRNA | ||
AL772253 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |