O34667 · LUXS_BACSU

Function

function

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Note: Binds 1 Fe cation per subunit.

Features

Showing features for binding site.

115720406080100120140
TypeIDPosition(s)Description
Binding site54Fe cation (UniProtKB | ChEBI)
Binding site58Fe cation (UniProtKB | ChEBI)
Binding site126Fe cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioniron ion binding
Molecular FunctionS-ribosylhomocysteine lyase activity
Biological Processquorum sensing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-ribosylhomocysteine lyase
  • EC number
  • Alternative names
    • AI-2 synthesis protein
    • Autoinducer-2 production protein LuxS

Gene names

    • Name
      luxS
    • Synonyms
      ytjB
    • Ordered locus names
      BSU30670

Organism names

Accessions

  • Primary accession
    O34667

Proteomes

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis57Complete loss of activity.
Mutagenesis57220-fold decrease in activity.
Mutagenesis84Complete loss of activity.
Mutagenesis84Almost complete loss of activity.

Chemistry

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001722111-157S-ribosylhomocysteine lyase

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Chemistry

Family & Domains

Sequence similarities

Belongs to the LuxS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    157
  • Mass (Da)
    17,714
  • Last updated
    1998-01-01 v1
  • Checksum
    DD011A2A88BD2FFB
MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPNKQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIVDLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF008220
EMBL· GenBank· DDBJ
AAC00235.1
EMBL· GenBank· DDBJ
Genomic DNA
AL009126
EMBL· GenBank· DDBJ
CAB15045.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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