O34651 · HISX_BACSU

Function

function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site123NAD+ (UniProtKB | ChEBI)
Binding site185NAD+ (UniProtKB | ChEBI)
Binding site208NAD+ (UniProtKB | ChEBI)
Binding site231substrate
Binding site253substrate
Binding site253Zn2+ (UniProtKB | ChEBI)
Binding site256substrate
Binding site256Zn2+ (UniProtKB | ChEBI)
Active site321Proton acceptor
Active site322Proton acceptor
Binding site322substrate
Binding site355substrate
Binding site355Zn2+ (UniProtKB | ChEBI)
Binding site409substrate
Binding site414substrate
Binding site414Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Molecular Functionhistidinol dehydrogenase activity
Molecular FunctionNAD binding
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histidinol dehydrogenase
  • EC number
  • Short names
    HDH

Gene names

    • Name
      hisD
    • Ordered locus names
      BSU34910

Organism names

Accessions

  • Primary accession
    O34651

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001357281-427Histidinol dehydrogenase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    427
  • Mass (Da)
    46,256
  • Last updated
    1998-01-01 v1
  • Checksum
    BDB0B2AE3C580E7F
MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAVRSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFYHRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDGLLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREVFGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVSAEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALLGSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQSAFEEHAESIAAFARLEGLEAHARSIEARERRISK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF017113
EMBL· GenBank· DDBJ
AAC67295.1
EMBL· GenBank· DDBJ
Genomic DNA
AL009126
EMBL· GenBank· DDBJ
CAB15496.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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