O34450 · NAGA_BACSU

Function

function

Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides (PubMed:14557261).
Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6-phosphate and acetate (PubMed:14557261).
Essential for growth on N-acetylglucosamine (PubMed:23667565).

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit.

Pathway

Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 4/5.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site63Fe cation 1 (UniProtKB | ChEBI)
Binding site65Fe cation 1 (UniProtKB | ChEBI)
Binding site136Fe cation 1 (UniProtKB | ChEBI)
Binding site136Fe cation 2 (UniProtKB | ChEBI)
Binding site147-148substrate
Binding site202Fe cation 2 (UniProtKB | ChEBI)
Binding site223Fe cation 2 (UniProtKB | ChEBI)
Binding site226-227substrate
Binding site234substrate
Binding site255-258substrate
Active site281Proton donor
Binding site281Fe cation 1 (UniProtKB | ChEBI)
Binding site314-316substrate

GO annotations

AspectTerm
Molecular Functioniron ion binding
Molecular FunctionN-acetylgalactosamine-6-phosphate deacetylase activity
Molecular FunctionN-acetylglucosamine-6-phosphate deacetylase activity
Molecular Functionprotein homodimerization activity
Biological ProcessN-acetylglucosamine catabolic process
Biological ProcessN-acetylneuraminate catabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylglucosamine-6-phosphate deacetylase
  • EC number
  • Short names
    GlcNAc 6-P deacetylase

Gene names

    • Name
      nagA
    • Ordered locus names
      BSU35010

Organism names

Accessions

  • Primary accession
    O34450

Proteomes

Phenotypes & Variants

Disruption phenotype

Deletion of the gene prevents growth on N-acetylglucosamine, but has no effect on growth on glucosamine.

Chemistry

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001709141-396N-acetylglucosamine-6-phosphate deacetylase

Proteomic databases

Expression

Induction

Expression is repressed by the HTH-type transcriptional regulator NagR.

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    396
  • Mass (Da)
    42,622
  • Last updated
    1998-01-01 v1
  • MD5 Checksum
    880D188D1C1128168EF426196FABBE52
MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYSKEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQEHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVELFKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGASHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKLILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNCSWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKEADQI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF017113
EMBL· GenBank· DDBJ
AAC67285.1
EMBL· GenBank· DDBJ
Genomic DNA
AL009126
EMBL· GenBank· DDBJ
CAB15506.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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