O30583 · COMP_ACIAD

Function

function

Pilin-like competence factor, which is essential for natural transformation of the Gram-negative soil bacterium A.baylyi ADP1. Is not a subunit of the pilus structures. Likely functions as a major subunit of an oligomeric structure acting as a channel or pore mediating DNA translocation through the outer membrane and periplasm.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell outer membrane
Cellular Componentperiplasmic space
Cellular Componentpilus
Cellular Componentplasma membrane
Molecular FunctionDNA binding
Biological Processcell adhesion
Biological Processestablishment of competence for transformation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pilin-like competence factor ComP

Gene names

    • Name
      comP
    • Ordered locus names
      ACIAD3338

Organism names

Accessions

  • Primary accession
    O30583
  • Secondary accessions
    • Q6F7F8

Proteomes

Subcellular Location

Cell inner membrane
Periplasm
Cell outer membrane
Note: The 20-kDa form is present in the cytoplasmic membrane, the periplasm, and the outer membrane, whereas the 23-kDa form is located in the outer membrane and might be due to a further modification.

Keywords

Phenotypes & Variants

Disruption phenotype

A deletion of comP completely abolishes natural transformation, due to a complete lack of DNA binding and, therefore, uptake of DNA, but has no effect on piliation and on twitching motility.

PTM/Processing

Features

Showing features for propeptide, modified residue, chain.

Type
IDPosition(s)Description
PropeptidePRO_00004337881-6
Modified residue7N-methylphenylalanine
ChainPRO_00004337897-147Pilin-like competence factor ComP

Post-translational modification

Glycosylated by PglL2 (PubMed:23658772).
The 20-kDa form is glycosylated; a 23-kDa form also exists, that might be due to a further modification. The glycosylation of ComP is not required for its function in DNA binding and uptake (PubMed:10850981).

Keywords

Expression

Induction

Is maximally expressed in the late stationary growth phase (at protein and mRNA level). Minimal comP expression levels are detected in the middle of the logarithmic growth phase.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the N-Me-Phe pilin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    147
  • Mass (Da)
    14,872
  • Last updated
    1998-01-01 v1
  • Checksum
    682DBC062230C479
MNAQKGFTLIELMIVIAIIGILAAIAIPAYTDYTVRARVSEGLTAASSMKTTVSENILNAGALVAGTPSTAGSSCVGVQEISASNATTNVATATCGASSAGQIIVTMDTTKAKGANITLTPTYASGAVTWKCTTTSDKKYVPSECRG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF012550
EMBL· GenBank· DDBJ
AAC45886.1
EMBL· GenBank· DDBJ
Genomic DNA
CR543861
EMBL· GenBank· DDBJ
CAG70007.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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