O30108 · NFI_ARCFU

Function

function

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Recognizes only deoxyinosine.

Catalytic activity

  • Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.
    EC:3.1.21.7 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Temperature Dependence

Optimum temperature is 85 degrees Celsius.

Features

Showing features for binding site, site.

122120406080100120140160180200220
TypeIDPosition(s)Description
Binding site38Mg2+ (UniProtKB | ChEBI)
Site74Interaction with target DNA
Binding site104Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiondeoxyribonuclease V activity
Molecular Functionmagnesium ion binding
Molecular FunctionRNA endonuclease activity, producing 5'-phosphomonoesters
Molecular Functionsingle-stranded RNA binding
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease V
  • EC number
  • Alternative names
    • Deoxyinosine 3'endonuclease
    • Deoxyribonuclease V
      (DNase V
      )

Gene names

    • Name
      nfi
    • Ordered locus names
      AF_0129

Organism names

Accessions

  • Primary accession
    O30108

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001596841-221Endonuclease V

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the endonuclease V family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    221
  • Mass (Da)
    24,872
  • Last updated
    1998-01-01 v1
  • Checksum
    69F5DA504644A45C
MLQMNLEELRRIQEEMSRSVVLEDLIPLEELEYVVGVDQAFISDEVVSCAVKLTFPELEVVDKAVRVEKVTFPYIPTFLMFREGEPAVNAVKGLVDDRAAIMVDGSGIAHPRRCGLATYIALKLRKPTVGITKKRLFGEMVEVEDGLWRLLDGSETIGYALKSCRRCKPIFISPGSYISPDSALELTRKCLKGYKLPEPIRIADKLTKEVKRELTPTSKLK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE000782
EMBL· GenBank· DDBJ
AAB91100.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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