O28305 · HEM2_ARCFU

Function

function

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per monomer.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site120Zn2+ (UniProtKB | ChEBI); catalytic
Binding site122Zn2+ (UniProtKB | ChEBI); catalytic
Binding site130Zn2+ (UniProtKB | ChEBI); catalytic
Active site195Schiff-base intermediate with substrate
Binding site2055-aminolevulinate 1 (UniProtKB | ChEBI)
Binding site2175-aminolevulinate 1 (UniProtKB | ChEBI)
Binding site233Mg2+ (UniProtKB | ChEBI)
Active site248Schiff-base intermediate with substrate
Binding site2745-aminolevulinate 2 (UniProtKB | ChEBI)
Binding site3125-aminolevulinate 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionporphobilinogen synthase activity
Molecular Functionzinc ion binding
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta-aminolevulinic acid dehydratase
  • EC number
  • Short names
    ALAD; ALADH
  • Alternative names
    • Porphobilinogen synthase

Gene names

    • Name
      hemB
    • Ordered locus names
      AF_1974

Organism names

Accessions

  • Primary accession
    O28305

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001405221-322Delta-aminolevulinic acid dehydratase

Proteomic databases

Interaction

Subunit

Homooctamer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the ALAD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    322
  • Mass (Da)
    36,398
  • Last updated
    1998-01-01 v1
  • Checksum
    5FE684E6B394B509
MAEFPKVRMRRLRKANLRWMFREARLSPENLITPIFVDENIKEKKPIESMPDYFRIPLEMVDKEVEECLEKDLRSFILFGIPSYKDETGSSAYDQNGVIQKAVRRIKAEFPDAVIVTDVCLCEYTTHGHCGVVKDGEIVNDETLPIIGKTAVSHAESGADIVAPSGMMDGMVKAIREALDAAGFESTPIMSYSAKYASNFYSPFRDAAESGFKFGDRRGYQMDIHNAREAMREIELDVKEGADIIMVKPALPYLDIIRMVRERFDLPLAAYNVSGEYSMIKAAIKNGWLSEEAIYEVLISIKRAGADLIITYHSKEIAEKLQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE000782
EMBL· GenBank· DDBJ
AAB89292.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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