O26652 · GGGPS_METTH
- ProteinGeranylgeranylglyceryl phosphate synthase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids245 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
Catalytic activity
- (2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate
Cofactor
Pathway
Membrane lipid metabolism; glycerophospholipid metabolism.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 22 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 51 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 169-175 | sn-glycerol 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: YLEAGSG | ||||||
Binding site | 200-201 | sn-glycerol 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: GG | ||||||
Binding site | 222-223 | sn-glycerol 1-phosphate (UniProtKB | ChEBI) | ||||
Sequence: GT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | imidazoleglycerol-phosphate synthase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | phosphoglycerol geranylgeranyltransferase activity | |
Biological Process | glycerophospholipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGeranylgeranylglyceryl phosphate synthase
- EC number
- Short namesGGGP synthase ; GGGPS ; MtGGGPS
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales > Methanobacteriaceae > Methanothermobacter
Accessions
- Primary accessionO26652
Proteomes
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 83 | Accepts HepPP as substrate. | ||||
Sequence: V → G | ||||||
Mutagenesis | 138 | Forms homodimers. Shows almost wild-type activity. | ||||
Sequence: W → A |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000138736 | 1-245 | Geranylgeranylglyceryl phosphate synthase | |||
Sequence: MKVEDYFHDILRERKIHLTLIDPEEQTPEEAVEIARAAIRGGTDGIMLGGSTTDSSELDNTARALRENIDVPIILFPGNTTGVSRYADAIFFMSLLNSTNPYWIIGAQALGAATVKKMGIEALPMGYLVVEPGGTVGWVGDTKPVPRNKPDIAAAYAMAAEFLGMRLFYLEAGSGAPEHVPEEMIALVKRCTDQILIVGGGIRSGEDAARVAGAGADVVVTGTVVENSDNVEDKIREIVEGMGSV |
Proteomic databases
Structure
Family & Domains
Sequence similarities
Belongs to the GGGP/HepGP synthase family. Group II subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length245
- Mass (Da)26,119
- Last updated2008-09-23 v2
- Checksum7CB5D1AFF72F1C53
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE000666 EMBL· GenBank· DDBJ | AAB85058.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |