O26249 · CBIT_METTH

Function

function

Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

Caution

Was originally thought to be a precorrin-8w decarboxylase.

Catalytic activity

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site17S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site41-45S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site62S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site91S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncobalt-precorrin-6B C5-methyltransferase activity
Molecular Functionprotein methyltransferase activity
Biological Processanaerobic cobalamin biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)
  • EC number

Gene names

    • Name
      cbiT
    • Ordered locus names
      MTH_146

Organism names

Accessions

  • Primary accession
    O26249

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001349411-192Probable cobalt-precorrin-6B C15-methyltransferase (decarboxylating)

Proteomic databases

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    192
  • Mass (Da)
    20,714
  • Last updated
    1998-01-01 v1
  • Checksum
    7BFA35D8BD3C3982
MIPDDEFIKNPSVPGPTAMEVRCLIMCLAEPGKNDVAVDVGCGTGGVTLELAGRVRRVYAIDRNPEAISTTEMNLQRHGLGDNVTLMEGDAPEALCKIPDIDIAVVGGSGGELQEILRIIKDKLKPGGRIIVTAILLETKFEAMECLRDLGFDVNITELNIARGRALDRGTMMVSRNPVALIYTGVSHENKD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE000666
EMBL· GenBank· DDBJ
AAB84652.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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