O26232 · PYRF_METTH
- ProteinOrotidine 5'-phosphate decarboxylase
- GenepyrF
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids228 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Catalytic activity
- H+ + orotidine 5'-phosphate = CO2 + UMP
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 20 | substrate | ||||
Sequence: D | ||||||
Binding site | 42 | substrate | ||||
Sequence: K | ||||||
Binding site | 70-79 | substrate | ||||
Sequence: DFKVADIPET | ||||||
Active site | 72 | Proton donor | ||||
Sequence: K | ||||||
Binding site | 127 | substrate | ||||
Sequence: S | ||||||
Binding site | 180-190 | substrate | ||||
Sequence: PGVGAQGGDPG | ||||||
Binding site | 202 | substrate | ||||
Sequence: G | ||||||
Binding site | 203 | substrate | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | orotidine-5'-phosphate decarboxylase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrotidine 5'-phosphate decarboxylase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales > Methanobacteriaceae > Methanothermobacter
Accessions
- Primary accessionO26232
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000134612 | 1-228 | Orotidine 5'-phosphate decarboxylase | |||
Sequence: MRSRRVDVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFRKRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFRGADSVRACLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKDLLNP |
Proteomic databases
Structure
Family & Domains
Sequence similarities
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length228
- Mass (Da)24,915
- Last updated1998-01-01 v1
- ChecksumA7B65D94C8663D78
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE000666 EMBL· GenBank· DDBJ | AAB84635.1 EMBL· GenBank· DDBJ | Genomic DNA |