O24650 · PROF2_PHLPR

Function

function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.

Miscellaneous

The variability of the residues taking part of IgE-binding epitopes might be responsible of the difference in cross-reactivity among olive pollen cultivars, and between distantly related pollen species, leading to a variable range of allergy reactions among atopic patients.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell cortex
Cellular Componentcytoskeleton
Molecular Functionactin monomer binding
Biological Processsequestering of actin monomers

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Profilin-2
  • Alternative names
    • Allergen Phl p 11
    • Pollen allergen Phl p 12
    • Profilin 4
  • Allergen name
    Phl p 12

Gene names

    • Name
      PRO2
    • Name
      PRO4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Pooideae > Poodae > Poeae > Poeae Chloroplast Group 2 (Poeae type) > Poodinae > Phleinae > Phleum

Accessions

  • Primary accession
    O24650

Subcellular Location

Phenotypes & Variants

Allergenic properties

Causes an allergic reaction in human. Binds to IgE.

Keywords

Protein family/group databases

PTM/Processing

Features

Showing features for initiator methionine, chain, disulfide bond, modified residue.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00001996642-131Profilin-2
Disulfide bond13↔115
Modified residue111Phosphothreonine

Post-translational modification

Phosphorylated by MAP kinases.

Keywords

Interaction

Subunit

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif81-97Involved in PIP2 interaction

Sequence similarities

Belongs to the profilin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    131
  • Mass (Da)
    14,150
  • Last updated
    1998-01-01 v1
  • Checksum
    1B97B9DA084AE14C
MSWQTYVDEHLMCEIEGHHLASAAILGHDGTVWAQSADFPQFKPEEITGIMKDFDEPGHLAPTGMFVAGAKYMVIQGEPGAVIRGKKGAGGITIKKTGQALVVGIYDEPMTPGQCNMVVERLGDYLVEQGM

Polymorphism

Several isoforms of the allergen exist due to polymorphism.

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y09456
EMBL· GenBank· DDBJ
CAA70608.1
EMBL· GenBank· DDBJ
mRNA
Y09458
EMBL· GenBank· DDBJ
CAA70610.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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