O24606 · EIN3_ARATH

Function

function

Transcription factor acting as a positive regulator in the ethylene response pathway, by promoting histone acetylation in an ENAP1-dependent manner, thus accelerating the expression of ethylene-responsive genes (PubMed:28874528).
Binds DNA (PubMed:26352699).
Is required for ethylene responsiveness in adult plant tissues. Binds a primary ethylene response element present in the ETHYLENE-RESPONSE-FACTOR1 promoter with consequence to activate the transcription of this gene

Miscellaneous

Loss-of-function mutations (ein3-1 and ein3-2) in the gene lead to the suppression of ethylene-mediated effects including gene expression, the triple response, cell growth inhibition, and accelerated senescence.

Activity regulation

Activated by phosphorylation by MPK3 and MPK6 (PubMed:18273012).
Down-regulated by KIN10 that controls its protein stability under a phosphorylation-dependent manner (PubMed:28600557).
Satnilitzed during hypoxia (e.g. submergences) via a ceramides-triggered and CTR1-dependent manner (PubMed:25822663).

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionhistone binding
Molecular Functionkinase binding
Molecular Functiontranscription cis-regulatory region binding
Biological Processdefense response to bacterium
Biological Processepigenetic regulation of gene expression
Biological Processethylene-activated signaling pathway
Biological Processregulation of DNA-templated transcription
Biological Processregulation of L-ascorbic acid biosynthetic process
Biological Processresponse to ethylene
Biological Processresponse to hypoxia
Biological Processsugar mediated signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein ETHYLENE INSENSITIVE 3

Gene names

    • Name
      EIN3
    • ORF names
      MOE17.8
    • Ordered locus names
      At3g20770

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    O24606
  • Secondary accessions
    • Q8VYW4

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis245In ein3-3; suppression of DNA-binding.

Variants

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The viewer provides 30 variants from UniProt as well as other sources including ClinVar and dbSNP.

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PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001134981-628Protein ETHYLENE INSENSITIVE 3

Post-translational modification

Phosphorylated by KIN10.

Proteomic databases

PTM databases

Expression

Induction

Accumuates upon hypoxia (e.g. submergences).

Gene expression databases

Interaction

Subunit

Acts as a homodimer to bind the primary ethylene response element. Interacts with TAF12B. Interacts with KIN10 (PubMed:28600557).
Binds to ENAP1 in the presence of ethylene; this reaction facilitates its association with histone (PubMed:27694846, PubMed:28874528).

Binary interactions

Protein-protein interaction databases

Family & Domains

Features

Showing features for coiled coil, region.

TypeIDPosition(s)Description
Coiled coil38-68
Region66-92Disordered
Region174-306DNA-binding domain

Sequence similarities

Belongs to the EIN3 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    628
  • Mass (Da)
    71,421
  • Last updated
    1998-01-01 v1
  • Checksum
    8DA269C9F2A3BFD3
MMFNEMGMCGNMDFFSSGSLGEVDFCPVPQAEPDSIVEDDYTDDEIDVDELERRMWRDKMRLKRLKEQDKGKEGVDAAKQRQSQEQARRKKMSRAQDGILKYMLKMMEVCKAQGFVYGIIPENGKPVTGASDNLREWWKDKVRFDRNGPAAITKYQAENNIPGIHEGNNPIGPTPHTLQELQDTTLGSLLSALMQHCDPPQRRFPLEKGVPPPWWPNGKEDWWPQLGLPKDQGPAPYKKPHDLKKAWKVGVLTAVIKHMFPDIAKIRKLVRQSKCLQDKMTAKESATWLAIINQEESLARELYPESCPPLSLSGGSCSLLMNDCSQYDVEGFEKESHYEVEELKPEKVMNSSNFGMVAKMHDFPVKEEVPAGNSEFMRKRKPNRDLNTIMDRTVFTCENLGCAHSEISRGFLDRNSRDNHQLACPHRDSRLPYGAAPSRFHVNEVKPVVGFPQPRPVNSVAQPIDLTGIVPEDGQKMISELMSMYDRNVQSNQTSMVMENQSVSLLQPTVHNHQEHLQFPGNMVEGSFFEDLNIPNRANNNNSSNNQTFFQGNNNNNNVFKFDTADHNNFEAAHNNNNNSSGNRFQLVFDSTPFDMASFDYRDDMSMPGVVGTMDGMQQKQQDVSIWF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF004216
EMBL· GenBank· DDBJ
AAC49749.1
EMBL· GenBank· DDBJ
mRNA
AF004217
EMBL· GenBank· DDBJ
AAC49750.1
EMBL· GenBank· DDBJ
Genomic DNA
AB025629
EMBL· GenBank· DDBJ
BAB02485.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE76421.1
EMBL· GenBank· DDBJ
Genomic DNA
AY069875
EMBL· GenBank· DDBJ
AAL47431.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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