O23304 · BLUS1_ARATH
- ProteinSerine/threonine-protein kinase BLUS1
- GeneBLUS1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids487 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Ser/Thr protein kinase mediating a primary step for phototropin signaling in guard cells. Essential for stomatal opening.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activator activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | regulation of stomatal opening |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase BLUS1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionO23304
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Defective in leaf temperature decreases and stomatal opening in response to blue light.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 157 | Loss of activity. | ||||
Sequence: D → N | ||||||
Mutagenesis | 192 | In blus1-2; loss of stomatal response to blue light. | ||||
Sequence: A → T | ||||||
Mutagenesis | 194 | In blus1-1; loss of stomatal response to blue light. | ||||
Sequence: E → K | ||||||
Mutagenesis | 348 | Loss of stomatal response to blue light. | ||||
Sequence: S → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 46 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000423824 | 1-487 | Serine/threonine-protein kinase BLUS1 | |||
Sequence: MARNKLEFPLDAEAYEIICKIGVGVSASVYKAICIPMNSMVVAIKAIDLDQSRADFDSLRRETKTMSLLSHPNILNAYCSFTVDRCLWVVMPFMSCGSLHSIVSSSFPSGLPENCISVFLKETLNAISYLHDQGHLHRDIKAGNILVDSDGSVKLADFGVSASIYEPVTSSSGTTSSSLRLTDIAGTPYWMAPEVVHSHTGYGFKADIWSFGITALELAHGRPPLSHLPPLKSLLMKITKRFHFSDYEINTSGSSKKGNKKFSKAFREMVGLCLEQDPTKRPSAEKLLKHPFFKNCKGLDFVVKNVLHSLSNAEQMFMESQILIKSVGDDDEEEEEEDEEIVKNRRISGWNFREDDLQLSPVFPATESDSSESSPREEDQSKDKKEDDNVTITGYELGLGLSNEEAKNQEGEVVGFDKDLVLEKLKVLKKSLEHQRARVSIIIEALSGDKEEKSREEELLEMVEKLKIELETEKLKTLRADKDSVLG | ||||||
Modified residue | 348 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylated at Ser-348 by both PHOT1 and PHOT2.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in guard cells. Not detected in mesophyll cells.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 15-293 | Protein kinase | ||||
Sequence: YEIICKIGVGVSASVYKAICIPMNSMVVAIKAIDLDQSRADFDSLRRETKTMSLLSHPNILNAYCSFTVDRCLWVVMPFMSCGSLHSIVSSSFPSGLPENCISVFLKETLNAISYLHDQGHLHRDIKAGNILVDSDGSVKLADFGVSASIYEPVTSSSGTTSSSLRLTDIAGTPYWMAPEVVHSHTGYGFKADIWSFGITALELAHGRPPLSHLPPLKSLLMKITKRFHFSDYEINTSGSSKKGNKKFSKAFREMVGLCLEQDPTKRPSAEKLLKHPFF | ||||||
Region | 363-389 | Disordered | ||||
Sequence: FPATESDSSESSPREEDQSKDKKEDDN | ||||||
Compositional bias | 371-389 | Basic and acidic residues | ||||
Sequence: SESSPREEDQSKDKKEDDN | ||||||
Coiled coil | 450-477 | |||||
Sequence: KEEKSREEELLEMVEKLKIELETEKLKT |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length487
- Mass (Da)54,381
- Last updated1998-01-01 v1
- Checksum77D21D39D2FB4F20
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 371-389 | Basic and acidic residues | ||||
Sequence: SESSPREEDQSKDKKEDDN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z97336 EMBL· GenBank· DDBJ | CAB10227.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL161539 EMBL· GenBank· DDBJ | CAB78490.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE83449.1 EMBL· GenBank· DDBJ | Genomic DNA |