O22886 · DCUP2_ARATH
- ProteinUroporphyrinogen decarboxylase 2, chloroplastic
- GeneHEME2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids394 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Catalytic activity
- uroporphyrinogen III + 4 H+ = coproporphyrinogen III + 4 CO2
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
Porphyrin-containing compound metabolism; chlorophyll biosynthesis.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 74-78 | substrate | ||||
Sequence: RQAGR | ||||||
Binding site | 93 | substrate | ||||
Sequence: F | ||||||
Binding site | 123 | substrate | ||||
Sequence: S | ||||||
Binding site | 124 | substrate | ||||
Sequence: D | ||||||
Site | 124 | Transition state stabilizer | ||||
Sequence: D | ||||||
Binding site | 201 | substrate | ||||
Sequence: Y | ||||||
Binding site | 256 | substrate | ||||
Sequence: S | ||||||
Binding site | 371 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chloroplast | |
Cellular Component | chloroplast envelope | |
Cellular Component | chloroplast stroma | |
Cellular Component | Golgi apparatus | |
Molecular Function | uroporphyrinogen decarboxylase activity | |
Biological Process | chlorophyll biosynthetic process | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUroporphyrinogen decarboxylase 2, chloroplastic
- EC number
- Short namesUPD2; URO-D2
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionO22886
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, transit peptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000036329 | ?-394 | Uroporphyrinogen decarboxylase 2, chloroplastic | |||
Sequence: MSILQVSTSSLSSSTLLSISPRKSLSSTKSCRIVRCSVEGTTVTERKVSATSEPLLLRAVKGEVVDRPPVWLMRQAGRYMKSYQTLCEKYPSFRDRSENADLVVEISLQPWKVFKPDGVILFSDILTPLSGMNIPFDIVKGKGPIIFNPPQSAADVAQVREFVPEESVPYVGEALRRLRNEVNNEAAVLGFVGAPFTLSSYVIEGGSSKNFTQIKRLAFSQPKVLHALLQKFTTSMITYIRYQADSGAQAVQIFDSWATELSPVDFEEFSLPYLKQIVEAVKQTHPNLPLILYASGSGGLLERLARTGVDVVSLDWTVDMAEGRDRLGRDIAVQGNVDPGVLFGSKEFITSRIHDTVKKAGRDKHILNLGHGIKVGTPEENVAHFFEVAQEIRY | ||||||
Transit peptide | 1-? | Chloroplast |
Proteomic databases
PTM databases
Expression
Induction
Up-regulated by light. Not regulated by circadian rhythm.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length394
- Mass (Da)43,580
- Last updated1998-01-01 v1
- ChecksumB97992D4EE1AD9A7
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC002336 EMBL· GenBank· DDBJ | AAB87587.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC09837.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY142634 EMBL· GenBank· DDBJ | AAN13092.1 EMBL· GenBank· DDBJ | mRNA |