O22469 · MSI3_ARATH
- ProteinWD-40 repeat-containing protein MSI3
- GeneMSI3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids424 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | Cul4-RING E3 ubiquitin ligase complex | |
Cellular Component | ISWI-type complex | |
Biological Process | chromatin organization |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameWD-40 repeat-containing protein MSI3
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionO22469
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Modified residue | 1 | N-acetylmethionine | ||||
Sequence: M | ||||||
Chain | PRO_0000051082 | 1-424 | WD-40 repeat-containing protein MSI3 | |||
Sequence: MAAEEGKDEAGLDQVEEEFSIWKRNTPFLYDLMISHPLEWPSLTLHWVPSTPIPYSKDPYFAVHKLILGTHTSGGAQDFLMVADVVIPTPDAEPGLGGRDQEPIVPKVEIKQKIRVDGEVNRARCMPQKPTLVGAKTSGSEVFLFDYARLSGKPQTSECDPDLRLMGHEQEGYGLAWSSFKEGYLLSGSQDQRICLWDVSATATDKVLNPMHVYEGHQSIIEDVAWHMKNENIFGSAGDDCQLVIWDLRTNQMQHQVKVHEREINYLSFNPFNEWVLATASSDSTVALFDLRKLTAPLHVLSKHEGEVFQVEWDPNHETVLASSGEDRRLMVWDINRVGDEQLEIELDAEDGPPELLFSHGGHKAKISDFAWNKDEPWVISSVAEDNSLQVWQMAESIYREDDEDEDDDDEGNQNAQHSNENQK |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O22469 | DDB1A Q9M0V3 | 2 | EBI-1632794, EBI-1632780 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat, motif, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 167-207 | WD 1 | ||||
Sequence: GHEQEGYGLAWSSFKEGYLLSGSQDQRICLWDVSATATDKV | ||||||
Repeat | 216-256 | WD 2 | ||||
Sequence: GHQSIIEDVAWHMKNENIFGSAGDDCQLVIWDLRTNQMQHQ | ||||||
Motif | 233-249 | DWD box | ||||
Sequence: IFGSAGDDCQLVIWDLR | ||||||
Repeat | 259-299 | WD 3 | ||||
Sequence: VHEREINYLSFNPFNEWVLATASSDSTVALFDLRKLTAPLH | ||||||
Repeat | 303-343 | WD 4 | ||||
Sequence: KHEGEVFQVEWDPNHETVLASSGEDRRLMVWDINRVGDEQL | ||||||
Repeat | 362-402 | WD 5 | ||||
Sequence: GHKAKISDFAWNKDEPWVISSVAEDNSLQVWQMAESIYRED | ||||||
Region | 394-424 | Disordered | ||||
Sequence: MAESIYREDDEDEDDDDEGNQNAQHSNENQK |
Domain
The DWD box is required for interaction with DDB1A.
Sequence similarities
Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length424
- Mass (Da)47,983
- Last updated2001-01-11 v2
- ChecksumD83E2B4913468A0A
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 223-224 | in Ref. 1; AAB70244 | ||||
Sequence: DV → EL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF016848 EMBL· GenBank· DDBJ | AAB70244.1 EMBL· GenBank· DDBJ | mRNA | ||
AL022023 EMBL· GenBank· DDBJ | CAA17770.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL161586 EMBL· GenBank· DDBJ | CAB80222.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE86455.1 EMBL· GenBank· DDBJ | Genomic DNA |