O22208 · BZP17_ARATH

Function

function

Transcriptional activator involved in salt and osmotic stress responses. Functions as a stress sensor and transducer in a signaling pathway that resembles an ER stress response. Following salt stress, BZIP17 is cleaved by SBT6.1 (S1P) and S2P at the C-terminus and the N-terminal bZIP component is translocated to the nucleus, where it activates the expression of salt stress response genes (PubMed:17662035).
Functions as a stress sensor and transducer in ER stress signaling pathway. ER stress induces proteolysis of BZIP17 by SBT6.1 (S1P) and S2P, and the N-terminal bZIP component is translocated to the nucleus, where it activates the expression and production of ER chaperones, as well as protein involved in brassinosteroid (BR) signaling, which is required for stress acclimation and growth (PubMed:20876872).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionsequence-specific DNA binding
Molecular Functiontranscription cis-regulatory region binding
Biological Processhyperosmotic salinity response
Biological Processpositive regulation of DNA-templated transcription
Biological Processregulation of DNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    bZIP transcription factor 17
  • Short names
    AtbZIP17

Gene names

    • Name
      BZIP17
    • Ordered locus names
      At2g40950

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    O22208
  • Secondary accessions
    • Q8L7E7

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein
Golgi apparatus membrane
; Single-pass membrane protein
Nucleus
Note: Translocates to the nucleus following salt treatment, heat shock or tunicamycin treatment (ER stress) (PubMed:17662035, PubMed:20876872).
Relocation of BZIP17 from ER to the nucleus occurs through the Golgi and is S2P-dependent (PubMed:20876872).

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-366Cytoplasmic
Transmembrane367-387Helical
Topological domain388-721Lumenal

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype under normal growth conditions, but mutant plants have increased sensitivity to salt-induced osmotic stress.

Variants

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The viewer provides 67 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00004319711-721bZIP transcription factor 17
Glycosylation450N-linked (GlcNAc...) asparagine
Glycosylation462N-linked (GlcNAc...) asparagine
Glycosylation609N-linked (GlcNAc...) asparagine
Glycosylation617N-linked (GlcNAc...) asparagine
Glycosylation643N-linked (GlcNAc...) asparagine
Glycosylation651N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with BZIP28.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain, motif.

Type
IDPosition(s)Description
Compositional bias1-22Pro residues
Region1-51Disordered
Compositional bias87-101Polar residues
Region87-232Disordered
Compositional bias142-173Polar residues
Compositional bias189-232Basic and acidic residues
Domain228-288bZIP
Region230-261Basic motif
Region267-274Leucine-zipper
Region337-359Disordered
Region422-462Disordered
Motif627-630RRIL cleavage motif

Sequence similarities

Belongs to the bZIP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    721
  • Mass (Da)
    78,438
  • Last updated
    2002-06-01 v2
  • Checksum
    486193285A74B21B
MAEPITKEQPPPPAPDPNSTYPPPSDFDSISIPPLDDHFSDQTPIGELMSDLGFPDGEFELTFDGMDDLYFPAENESFLIPINTSNQEQFGDFTPESESSGISGDCIVPKDADKTITTSGCINRESPRDSDDRCSGADHNLDLPTPLSSQGSGNCGSDVSEATNESSPKSRNVAVDQKVKVEEAATTTTSITKRKKEIDEDLTDESRNSKYRRSGEDADASAVTGEEDEKKRARLMRNRESAQLSRQRKKHYVEELEEKVRNMHSTITDLNGKISYFMAENATLRQQLGGNGMCPPHLPPPPMGMYPPMAPMPYPWMPCPPYMVKQQGSQVPLIPIPRLKPQNTLGTSKAKKSESKKSEAKTKKVASISFLGLLFCLFLFGALAPIVNVNYGGISGAFYGNYRSNYITDQIYSQHRDRVLDTSRSGAGTGVSNSNGMHRGRDSDRGARKNISATESSVTPGNGSEPLVASLFVPRNDKLVKIDGNLIINSILASEKAVASRKASESKERKADLMISKDYTPALPLPDVGRTEELAKHLYRSKAEKQKALSSGSADTLKDQVKTKAANGEMQQWFREGVAGPMFSSGMCTEVFQFDVSSTSGAIIPAATNVSAEHGKNTTDTHKQQNRRILRGLPIPLPGSDFNLTKEHQRNSSSKEIKPASSMVVSVLVDPREGGDGDIDGMIGGPKSLSRVFVVVLLDSAKYVTYSCVLPRSGAPHLVTT

Features

Showing features for compositional bias, sequence conflict.

Type
IDPosition(s)Description
Compositional bias1-22Pro residues
Compositional bias87-101Polar residues
Compositional bias142-173Polar residues
Compositional bias189-232Basic and acidic residues
Sequence conflict487in Ref. 3; AAM96961/AAN15727

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC002409
EMBL· GenBank· DDBJ
AAB86455.2
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
AEC09905.1
EMBL· GenBank· DDBJ
Genomic DNA
AY136295
EMBL· GenBank· DDBJ
AAM96961.1
EMBL· GenBank· DDBJ
mRNA
BT000408
EMBL· GenBank· DDBJ
AAN15727.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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