O22040 · ANP1_ARATH

Function

function

May be involved in an oxidative stress-mediated signaling cascade that phosphorylates downstream MAP kinases MPK3 and MPK6. May suppress auxin signaling that promotes cell cycle. Functionally redundant to ANP2 and ANP3 in the positive regulation of cytokinesis.

Miscellaneous

The protein kinase activity of isoform 1S is higher than that of isoform 1L.

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site75-83ATP (UniProtKB | ChEBI)
Binding site98ATP (UniProtKB | ChEBI)
Active site197Proton acceptor

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionMAP kinase kinase kinase activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processprotein autophosphorylation
Biological Processresponse to oxidative stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitogen-activated protein kinase kinase kinase ANP1
  • EC number
  • Alternative names
    • Arabidopsis NPK1-related kinase 1

Gene names

    • Name
      ANP1
    • ORF names
      F7G19.13
    • Ordered locus names
      At1g09000

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    O22040
  • Secondary accessions
    • O04030
    • O22039
    • Q8GZ05

Proteomes

Organism-specific databases

Genome annotation databases

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis98Loss of kinase activity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 44 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, cross-link.

TypeIDPosition(s)Description
ChainPRO_00000862701-666Mitogen-activated protein kinase kinase kinase ANP1
Cross-link109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross-link111Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords

Proteomic databases

Expression

Tissue specificity

Expressed in roots, inflorescence stems, flower buds and flowers. Low amount in rosette and cauline leaves.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias.

TypeIDPosition(s)Description
Domain69-331Protein kinase
Coiled coil101-131
Region452-481Disordered
Region536-592Disordered
Compositional bias550-587Polar residues
Coiled coil620-643
Region635-666Disordered
Compositional bias650-666Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

O22040-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    666
  • Mass (Da)
    73,470
  • Last updated
    2004-04-26 v2
  • Checksum
    588C6339CDC58C18
MQDFFGSVRRSLVFRPSSDDDNQENQPPFPGVLADKITSCIRKSKIFIKPSFSPPPPANTVDMAPPISWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGTVREDDTLNILLEFVPGGSISSLLEKFGPFPESVVRTYTRQLLLGLEYLHNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLSSDAKDFLLKCLQEVPNLRPTASELLKHPFVMGKHKESASTDLGSVLNNLSTPLPLQINNTKSTPDSTCDDVGDMCNFGSLNYSLVDPVKSIQNKNLWQQNDNGGDEDDMCLIDDENFLTFDGEMSSTLEKDCHLKKSCDDISDMSIALKSKFDESPGNGEKESTMSMECDQPSYSEDDDELTESKIKAFLDEKAADLKKLQTPLYEEFYNSLITFSPSCMESNLSNSKREDTARGFLKLPPKSRSPSRGPLGGSPSRATDATSCSKSPGSGGSRELNINNGGDEASQDGVSARVTDWRGLVVDTKQELSQCVALSEIEKKWKEELDQELERKRQEIMRQAGLGSSPRDRGMSRQREKSRFASPGK

O22040-2

  • Name
    1S
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8AWJ5A0A1P8AWJ5_ARATHNP1620

Sequence caution

The sequence AAB70419.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_010124372-376in isoform 1S
Alternative sequenceVSP_010125377-666in isoform 1S
Compositional bias550-587Polar residues
Compositional bias650-666Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB000796
EMBL· GenBank· DDBJ
BAA21854.1
EMBL· GenBank· DDBJ
mRNA
AB000797
EMBL· GenBank· DDBJ
BAA21855.1
EMBL· GenBank· DDBJ
mRNA
AC000106
EMBL· GenBank· DDBJ
AAB70419.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002684
EMBL· GenBank· DDBJ
AEE28381.1
EMBL· GenBank· DDBJ
Genomic DNA
AK117282
EMBL· GenBank· DDBJ
BAC41954.1
EMBL· GenBank· DDBJ
mRNA
BT005949
EMBL· GenBank· DDBJ
AAO64884.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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