O21325 · NU1M_DASNO
- ProteinNADH-ubiquinone oxidoreductase chain 1
- GeneMT-ND1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids318 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Catalytic activity
- a ubiquinone + NADH + 5 H+(in) = a ubiquinol + NAD+ + 4 H+(out)
a ubiquinone RHEA-COMP:9565 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= a ubiquinol RHEA-COMP:9566 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex I | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Molecular Function | NADH dehydrogenase activity | |
Biological Process | mitochondrial electron transport, NADH to ubiquinone | |
Biological Process | mitochondrial respiratory chain complex I assembly |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 1
- EC number
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Xenarthra > Cingulata > Dasypodidae > Dasypus
Accessions
- Primary accessionO21325
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 3-23 | Helical | ||||
Sequence: LINVLSLIIPILLAVAFLTLL | ||||||
Transmembrane | 69-89 | Helical | ||||
Sequence: LMFTLAPTLALTLALSLWIPI | ||||||
Transmembrane | 100-120 | Helical | ||||
Sequence: LGVLFILAMSSLAVYSILWSG | ||||||
Transmembrane | 135-155 | Helical | ||||
Sequence: AVAQTISYEVTLAIILLSIMM | ||||||
Transmembrane | 171-191 | Helical | ||||
Sequence: HMWLIFPLWPLAMMWFISTLA | ||||||
Transmembrane | 223-243 | Helical | ||||
Sequence: FFLAEYANIIMMNALTAILFF | ||||||
Transmembrane | 253-273 | Helical | ||||
Sequence: ELHTLNLITKTLILTMMFLWV | ||||||
Transmembrane | 293-313 | Helical | ||||
Sequence: FLPLTLALCMLHVSAPATFAG |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000117380 | 1-318 | NADH-ubiquinone oxidoreductase chain 1 | |||
Sequence: MYLINVLSLIIPILLAVAFLTLLERKILGYMQLRKGPNIVGPYGLLQPIADAIKLFIKEPLRPATSSKLMFTLAPTLALTLALSLWIPIPMPYPLVNLNLGVLFILAMSSLAVYSILWSGWASNSKYALIGALRAVAQTISYEVTLAIILLSIMMTNGSFTLSTLTTTQEHMWLIFPLWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFLAEYANIIMMNALTAILFFGAMHNPMFPELHTLNLITKTLILTMMFLWVRASYPRFRYDQLMHLLWKSFLPLTLALCMLHVSAPATFAGVPPHM |
Structure
Sequence
- Sequence statusComplete
- Length318
- Mass (Da)35,582
- Last updated1998-01-01 v1
- Checksum26E2DB45E712FF6A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Y11832 EMBL· GenBank· DDBJ | CAA72529.1 EMBL· GenBank· DDBJ | Genomic DNA |