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O19186 · O19186_SHEEP

  • Protein
    Calpastatin
  • Gene
    CAST
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Functioncalcium-dependent cysteine-type endopeptidase inhibitor activity
Biological Processinhibition of cysteine-type endopeptidase activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Calpastatin
  • Alternative names
    • Calpain inhibitor

Gene names

    • Name
      CAST
    • Synonyms
      Cast

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Dorset Down
    • 8A
    • 13A
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Ovis

Accessions

  • Primary accession
    O19186

Subcellular Location

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-46Disordered

Sequence similarities

Belongs to the protease inhibitor I27 (calpastatin) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    46
  • Mass (Da)
    4,937
  • Last updated
    2004-07-05 v2
  • MD5 Checksum
    89EACBC14706F9124F9FBCB5EA0E6404
LSSDFTCSSPTADAKKTEKEKSTEEALKAQSAGVIRSAAPPKEKRR

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue46

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF016006
EMBL· GenBank· DDBJ
AAB88415.1
EMBL· GenBank· DDBJ
Genomic DNA
AF016007
EMBL· GenBank· DDBJ
AAB88416.1
EMBL· GenBank· DDBJ
Genomic DNA
AF016008
EMBL· GenBank· DDBJ
AAD04196.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ390049
EMBL· GenBank· DDBJ
AEY68565.1
EMBL· GenBank· DDBJ
Genomic DNA
JQ390050
EMBL· GenBank· DDBJ
AEY68566.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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