O19113 · CCN2_PIG
- ProteinCCN family member 2
- GeneCCN2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids349 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity).
Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity).
Enhances fibroblast growth factor-induced DNA synthesis (By similarity).
Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity).
Enhances fibroblast growth factor-induced DNA synthesis (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular matrix | |
Cellular Component | extracellular space | |
Molecular Function | heparin binding | |
Molecular Function | integrin binding | |
Biological Process | cell adhesion | |
Biological Process | DNA biosynthetic process | |
Biological Process | positive regulation of cell differentiation | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCCN family member 2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus
Accessions
- Primary accessionO19113
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MSATGLSPVRCAFVLLLALCSRPASG | ||||||
Chain | PRO_0000014404 | 27-349 | CCN family member 2 | |||
Sequence: QDCSGQCQCAAGKRRACPAGVSLVLDGCGCCRLCAKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDHTVVGPALAAYRLEDTFGPDPTMMRANCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA | ||||||
Disulfide bond | 29↔54 | |||||
Sequence: CSGQCQCAAGKRRACPAGVSLVLDGC | ||||||
Disulfide bond | 33↔56 | |||||
Sequence: CQCAAGKRRACPAGVSLVLDGCGC | ||||||
Disulfide bond | 35↔57 | |||||
Sequence: CAAGKRRACPAGVSLVLDGCGCC | ||||||
Disulfide bond | 43↔60 | |||||
Sequence: CPAGVSLVLDGCGCCRLC | ||||||
Disulfide bond | 68↔82 | |||||
Sequence: CTERDPCDPHKGLFC | ||||||
Disulfide bond | 74↔95 | |||||
Sequence: CDPHKGLFCDFGSPANRKIGVC | ||||||
Disulfide bond | 256↔293 | |||||
Sequence: CIRTPKISKPVKFELSGCTSVKTYRAKFCGVCTDGRCC | ||||||
Disulfide bond | 273↔307 | |||||
Sequence: CTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKC | ||||||
Disulfide bond | 284↔323 | |||||
Sequence: CGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTC | ||||||
Disulfide bond | 287↔325 | |||||
Sequence: CTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCAC | ||||||
Disulfide bond | 292↔329 | |||||
Sequence: CCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHYNC |
Keywords
- PTM
Proteomic databases
Interaction
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 27-98 | IGFBP N-terminal | ||||
Sequence: QDCSGQCQCAAGKRRACPAGVSLVLDGCGCCRLCAKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAK | ||||||
Domain | 101-167 | VWFC | ||||
Sequence: APCVFGGTVYRSGESFQSSCKYQCTCLDGAVGCVPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCD | ||||||
Domain | 198-243 | TSP type-1 | ||||
Sequence: NCLVQTTEWSACSKTCGMGISTRVTNDNAFCRLEKQSRLCMVRPCE | ||||||
Region | 247-349 | Heparin-binding | ||||
Sequence: EENIKKGKKCIRTPKISKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA | ||||||
Domain | 256-330 | CTCK | ||||
Sequence: CIRTPKISKPVKFELSGCTSVKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKSMMFIKTCACHYNCP |
Sequence similarities
Belongs to the CCN family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length349
- Mass (Da)38,007
- Last updated1998-01-01 v1
- ChecksumBB510E2B2B52D4A0
Keywords
- Technical term