O18824 · SCRB1_BOVIN
- ProteinScavenger receptor class B member 1
- GeneSCARB1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids509 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | caveola | |
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | lipid binding | |
Molecular Function | low-density lipoprotein particle binding | |
Molecular Function | scavenger receptor activity | |
Biological Process | cholesterol efflux | |
Biological Process | cholesterol import | |
Biological Process | plasma lipoprotein particle clearance | |
Biological Process | recognition of apoptotic cell |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameScavenger receptor class B member 1
- Short namesSRB1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionO18824
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane, caveola ; Multi-pass membrane protein
Note: Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-11 | Cytoplasmic | ||||
Sequence: MGNLSRARRVT | ||||||
Transmembrane | 12-32 | Helical | ||||
Sequence: AALGFIGLLFAVLGIIMIVMV | ||||||
Topological domain | 33-440 | Extracellular | ||||
Sequence: PSIIKQQVLKNVRIDPNSLSFNMWKEIPVPFYLSVYFFNIVNPEGIIQGQKPQVQEHGPYVYREFRHKSNITFNNNDTVSFLEYRSYQFQPDKSRGQESDYIVMPNILVLSASMMMENRPGLLKLMMTLAFSTLGQRAFMNRTVGEIMWGYDDPLIHLINQYFPNSLPFKGKFGLFAELNNSDSGLFTVFTGVKNFSRIHLVDKWNGVSKVNYWHSDQCNMINGTSGQMWAPFMTPESSLEFYSPEACRSMKLVYKEQGVFGGIPTFRFVAPSTLFANGSVYPPNEGFCPCRESGIQNVSTCRFNAPLFLSHPHFYNADPVLAEAVSGLHPNPKEHSLFLDIHPVTGIPMNCSVKLQLSLFVKSVKGIGQTGNIQPVVLPLMWFEESGAMEGETLETFYIQLVLMPKV | ||||||
Transmembrane | 441-461 | Helical | ||||
Sequence: LHYAQYVLLALGCVLLLIPII | ||||||
Topological domain | 462-509 | Cytoplasmic | ||||
Sequence: YQIRSQEKCYLFWISFKKGSKDKEAVQAYSEFLMTSAPKGTVLQEARL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000144158 | 1-509 | Scavenger receptor class B member 1 | |||
Sequence: MGNLSRARRVTAALGFIGLLFAVLGIIMIVMVPSIIKQQVLKNVRIDPNSLSFNMWKEIPVPFYLSVYFFNIVNPEGIIQGQKPQVQEHGPYVYREFRHKSNITFNNNDTVSFLEYRSYQFQPDKSRGQESDYIVMPNILVLSASMMMENRPGLLKLMMTLAFSTLGQRAFMNRTVGEIMWGYDDPLIHLINQYFPNSLPFKGKFGLFAELNNSDSGLFTVFTGVKNFSRIHLVDKWNGVSKVNYWHSDQCNMINGTSGQMWAPFMTPESSLEFYSPEACRSMKLVYKEQGVFGGIPTFRFVAPSTLFANGSVYPPNEGFCPCRESGIQNVSTCRFNAPLFLSHPHFYNADPVLAEAVSGLHPNPKEHSLFLDIHPVTGIPMNCSVKLQLSLFVKSVKGIGQTGNIQPVVLPLMWFEESGAMEGETLETFYIQLVLMPKVLHYAQYVLLALGCVLLLIPIIYQIRSQEKCYLFWISFKKGSKDKEAVQAYSEFLMTSAPKGTVLQEARL | ||||||
Glycosylation | 102 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 108 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 173 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 212 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 227 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 251↔384 | |||||
Sequence: CNMINGTSGQMWAPFMTPESSLEFYSPEACRSMKLVYKEQGVFGGIPTFRFVAPSTLFANGSVYPPNEGFCPCRESGIQNVSTCRFNAPLFLSHPHFYNADPVLAEAVSGLHPNPKEHSLFLDIHPVTGIPMNC | ||||||
Glycosylation | 255 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 310 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 330 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 383 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
N-glycosylated.
The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length509
- Mass (Da)57,610
- Last updated1998-01-01 v1
- ChecksumB3B7FD368C22C12F
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A4IFC6 | A4IFC6_BOVIN | SCARB1 | 506 | ||
A0AAF6YZS3 | A0AAF6YZS3_BOVIN | SCARB1 | 440 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF019384 EMBL· GenBank· DDBJ | AAB70920.1 EMBL· GenBank· DDBJ | mRNA |