O18388 · IMB_DROME

Function

function

Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins (PubMed:11102382).
In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup (PubMed:23885126).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnuclear envelope
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular ComponentP granule
Molecular Functionnuclear import signal receptor activity
Molecular Functionnuclear localization sequence binding
Molecular Functionsmall GTPase binding
Biological Processchorion-containing eggshell formation
Biological Processmitotic cell cycle
Biological ProcessNLS-bearing protein import into nucleus
Biological Processprotein import into nucleus
Biological Processregulation of nucleocytoplasmic transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Importin subunit beta
  • Alternative names
    • Karyopherin subunit beta
    • Protein ketel

Gene names

    • Name
      Fs(2)Ket
    • ORF names
      CG2637

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    O18388
  • Secondary accessions
    • Q540Y0
    • Q9V3E6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001207621-884Importin subunit beta

Proteomic databases

Expression

Tissue specificity

Ubiquitously expressed in embryos.

Developmental stage

Expressed both maternally and zygotically.

Gene expression databases

Interaction

Subunit

Forms a complex with an importin alpha subunit (By similarity).
Interacts with the sesquiterpenoid juvenile hormone receptor Met (PubMed:27979731).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for repeat, domain, region.

TypeIDPosition(s)Description
Repeat8-37HEAT 1
Domain27-107Importin N-terminal
Repeat39-71HEAT 2
Repeat91-129HEAT 3
Repeat135-166HEAT 4
Repeat176-208HEAT 5
Repeat218-253HEAT 6
Repeat259-308HEAT 7
Repeat320-366HEAT 8
Region335-348IAB
Region340-425Ran-GTP binding
Repeat370-400HEAT 9
Repeat408-444HEAT 10
Repeat455-491HEAT 11
Repeat505-542HEAT 12
Repeat549-597HEAT 13
Repeat605-645HEAT 14
Repeat650-687HEAT 15
Repeat692-730HEAT 16
Repeat738-782HEAT 17
Repeat792-835HEAT 18
Repeat837-878HEAT 19

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    884
  • Mass (Da)
    98,696
  • Last updated
    2000-12-01 v2
  • Checksum
    DE6DACB927B314EC
MTSDIAMQLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINRWPMLIQTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDRSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLDDAIITQFLAEGKRSKAQRTKMLCTWAVKEIKKINTQVITQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
M9NDC3M9NDC3_DROMEFs(2)Ket884

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ002729
EMBL· GenBank· DDBJ
CAA05691.2
EMBL· GenBank· DDBJ
Genomic DNA
AF222745
EMBL· GenBank· DDBJ
AAF34680.1
EMBL· GenBank· DDBJ
mRNA
AE014134
EMBL· GenBank· DDBJ
AAF53918.1
EMBL· GenBank· DDBJ
Genomic DNA
AY118657
EMBL· GenBank· DDBJ
AAM50026.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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