O18388 · IMB_DROME
- ProteinImportin subunit beta
- GeneFs(2)Ket
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids884 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins (PubMed:11102382).
In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup (PubMed:23885126).
In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup (PubMed:23885126).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nuclear envelope | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Cellular Component | P granule | |
Molecular Function | nuclear import signal receptor activity | |
Molecular Function | nuclear localization sequence binding | |
Molecular Function | small GTPase binding | |
Biological Process | chorion-containing eggshell formation | |
Biological Process | mitotic cell cycle | |
Biological Process | NLS-bearing protein import into nucleus | |
Biological Process | protein import into nucleus | |
Biological Process | regulation of nucleocytoplasmic transport |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameImportin subunit beta
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionO18388
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000120762 | 1-884 | Importin subunit beta | |||
Sequence: MTSDIAMQLIAILEKTVSPDKNELLSAKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINRWPMLIQTLVNKVVSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAATTALHNSLEFTKSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDIIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAAVTNDGETPETYALSPYFEYIITQLLETTDRSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVLRKVHEQDAPQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLDDAIITQFLAEGKRSKAQRTKMLCTWAVKEIKKINTQVITQ |
Proteomic databases
Expression
Tissue specificity
Ubiquitously expressed in embryos.
Developmental stage
Expressed both maternally and zygotically.
Gene expression databases
Structure
Family & Domains
Features
Showing features for repeat, domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 8-37 | HEAT 1 | ||||
Sequence: QLIAILEKTVSPDKNELLSAKNFLEQAAAS | ||||||
Domain | 27-107 | Importin N-terminal | ||||
Sequence: AKNFLEQAAASNLPEFLKALSEILVNTANSAVARMAAGLQLKNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGT | ||||||
Repeat | 39-71 | HEAT 2 | ||||
Sequence: LPEFLKALSEILVNTANSAVARMAAGLQLKNHL | ||||||
Repeat | 91-129 | HEAT 3 | ||||
Sequence: SEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPI | ||||||
Repeat | 135-166 | HEAT 4 | ||||
Sequence: LIQTLVNKVVSEGSSEMHRESALEAIGYICQD | ||||||
Repeat | 176-208 | HEAT 5 | ||||
Sequence: SNDVLTAIIHGMRKVEPSNHVRLAATTALHNSL | ||||||
Repeat | 218-253 | HEAT 6 | ||||
Sequence: DMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTL | ||||||
Repeat | 259-308 | HEAT 7 | ||||
Sequence: EPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATD | ||||||
Repeat | 320-366 | HEAT 8 | ||||
Sequence: YARGALQFLTPVLVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCE | ||||||
Region | 335-348 | IAB | ||||
Sequence: KLTKQDECDDEDTW | ||||||
Region | 340-425 | Ran-GTP binding | ||||
Sequence: DECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYD | ||||||
Repeat | 370-400 | HEAT 9 | ||||
Sequence: VPHVLPFIKENIESPNWRFRDAAVMTFGSVL | ||||||
Repeat | 408-444 | HEAT 10 | ||||
Sequence: LKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGRICDI | ||||||
Repeat | 455-491 | HEAT 11 | ||||
Sequence: LQTLLECFVKSLKSEPRVAANVCWAFIGLSDAAWEAA | ||||||
Repeat | 505-542 | HEAT 12 | ||||
Sequence: SPYFEYIITQLLETTDRSDGAQANLRCAAYQALMDMIK | ||||||
Repeat | 549-597 | HEAT 13 | ||||
Sequence: YLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCATLQSVL | ||||||
Repeat | 605-645 | HEAT 14 | ||||
Sequence: APQISDAIMTALLTMFNSSAGKSGVVQEEAFLAVSTLVELL | ||||||
Repeat | 650-687 | HEAT 15 | ||||
Sequence: AKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGDIFRAL | ||||||
Repeat | 692-730 | HEAT 16 | ||||
Sequence: VPYSNEIMTVLINNLTEPTIHRTVKPQVLSAFGDIALSI | ||||||
Repeat | 738-782 | HEAT 17 | ||||
Sequence: LSMVLDMLRVASNLQTDANNFDMNEYINELRESILEAYTGIIQGL | ||||||
Repeat | 792-835 | HEAT 18 | ||||
Sequence: DVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSF | ||||||
Repeat | 837-878 | HEAT 19 | ||||
Sequence: PRLYPLLDDAIITQFLAEGKRSKAQRTKMLCTWAVKEIKKIN |
Sequence similarities
Belongs to the importin beta family. Importin beta-1 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length884
- Mass (Da)98,696
- Last updated2000-12-01 v2
- ChecksumDE6DACB927B314EC
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
M9NDC3 | M9NDC3_DROME | Fs(2)Ket | 884 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ002729 EMBL· GenBank· DDBJ | CAA05691.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF222745 EMBL· GenBank· DDBJ | AAF34680.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014134 EMBL· GenBank· DDBJ | AAF53918.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY118657 EMBL· GenBank· DDBJ | AAM50026.1 EMBL· GenBank· DDBJ | mRNA |