O17953 · DLDH_CAEEL
- ProteinDihydrolipoyl dehydrogenase, mitochondrial
- Genedld-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids495 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Miscellaneous
The active site is a redox-active disulfide bond.
Catalytic activity
- N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD+ = N6-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H+
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 59-68 | FAD (UniProtKB | ChEBI) | |||
Binding site | 77 | FAD (UniProtKB | ChEBI) | |||
Binding site | 169-171 | FAD (UniProtKB | ChEBI) | |||
Binding site | 206-213 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 229 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 264 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 299 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 340 | FAD (UniProtKB | ChEBI) | |||
Binding site | 346-349 | FAD (UniProtKB | ChEBI) | |||
Active site | 472 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial matrix | |
Cellular Component | mitochondrion | |
Cellular Component | oxoglutarate dehydrogenase complex | |
Molecular Function | dihydrolipoyl dehydrogenase activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydrolipoyl dehydrogenase, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionO17953
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, transit peptide, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000421278 | ?-495 | Dihydrolipoyl dehydrogenase, mitochondrial | ||
Transit peptide | 1-? | Mitochondrion | |||
Disulfide bond | 68↔73 | Redox-active | |||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Structure
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
O17953-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Namea
- Length495
- Mass (Da)52,633
- Last updated2003-03-01 v2
- Checksum77EB4A2FA935F0F6
O17953-2
- Nameb
- Differences from canonical
- 1-345: Missing
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_045381 | 1-345 | in isoform b | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z82277 EMBL· GenBank· DDBJ | CAB05249.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z82277 EMBL· GenBank· DDBJ | CBK19462.1 EMBL· GenBank· DDBJ | Genomic DNA |