O17679 · SET6_CAEEL

  • Protein
    Histone-lysine N-methyltransferase set-6
  • Gene
    set-6
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Histone methyltransferase that specifically di- and trimethylates 'Lys-9' of histone H3 (H3K9me2 and H3K9me3, respectively); involved in positively modulating the rate of age-related behavioral deterioration (PubMed:32103178).
May repress the expression of mitochondrial function-related genes by occupying their promoter regions, working in concert with probable chromatin reader protein, baz-2 (PubMed:32103178).
Involved in modulation of the mitochondrial unfolded protein response (UPR) (PubMed:32103178).
Regulates level of expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase) (PubMed:32103178).
Negatively modulates levels of endogenous 5-HT and dopamine with aging (PubMed:32103178).
Involved in modulating longevity, probably as a result of enhanced stress resistance via mechanisms related to dietary restriction and mitochondrial function (PubMed:32103178).

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site598S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromatin
Cellular Componentnucleus
Molecular Functionhistone H3K9 dimethyltransferase activity
Molecular Functionhistone H3K9 trimethyltransferase activity
Molecular Functionhistone H3K9me2 methyltransferase activity
Biological Processepigenetic regulation of gene expression
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      set-6
    • ORF names
      C49F5.2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    O17679

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown prevents age-related decline in the expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase) (PubMed:32103178).
RNAi-mediated knockdown improves behavioral performance in pharyngeal pumping in aged worms (PubMed:32103178).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004521781-708Histone-lysine N-methyltransferase set-6

Proteomic databases

Expression

Tissue specificity

Broadly expressed in the nervous system, including head, body and tail neurons.

Developmental stage

Expression increases with age.

Gene expression databases

    • WBGene00008206Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues

Interaction

Subunit

Interacts with baz-2.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region36-63Disordered
Compositional bias38-63Polar residues
Region101-152Disordered
Compositional bias127-142Polar residues
Domain455-599SET

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    708
  • Mass (Da)
    82,093
  • Last updated
    2002-10-01 v2
  • Checksum
    CF4B968F8BB88312
MERSRTGGSSTYSMSTANVPIITISDDDDELTIWEEPRKSPISSNSYSDERNHSLSSTSNSSVERSIIITISDDESEATERNQQEVVDRAISNNLTEKRRRSVESFHRLHSKERKLEVKSRKKSRTSSSSMEASTSCTFPARQTKTKRHKRKTYSTISSFAPHHSTICAELRNVNPARIADFRHPSIFEYSDMSLNERREHWKKEMKVIKKHNDIRLMHEEAVRFDDIIELDPTLNGYYRRFMGAEQSTRALFMAVRCLATFGRNFYEEPERDHGEEEIPEELDRYFEKLIYVAPRTRIRITDDIHLSNDTHRIPVYTDAKGETLKTVKIPNPLLYDHIINNMVDKVKEPLLYEAIKIAGSSENVIRCKCCSQDPVVNCFDNKDCPCFIANQFLQSRNKTTDTNEKLKFHTFQPLMYNDGNPTYYNTVGFACSPKCACKGACTNNATYLIQKKLYSIEIYRADPQIGFGIRSTLFIPAGTPIIEYCGELVDGERLHSSLENYSYQLTDCEGDKHLYNLLREKYKNNPEYYDVLDELSKHHFHLDAKMQGSVGRFANHSCTPNMEPLRLFKEGFTPANMRMIFFTLKDIFPGEPLTLDYGSEYKVFRRQRCLCRTFACRSGPHYEKFSNLDGKLIASCFVRLHHASRIRYSVDLQLIERFYSVGKVEEVRVDPCVSFSKYNLKWRRQLSTATCERLENVIEIELSDEDS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias38-63Polar residues
Compositional bias127-142Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284606
EMBL· GenBank· DDBJ
CAB03974.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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