O17679 · SET6_CAEEL
- ProteinHistone-lysine N-methyltransferase set-6
- Geneset-6
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids708 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Histone methyltransferase that specifically di- and trimethylates 'Lys-9' of histone H3 (H3K9me2 and H3K9me3, respectively); involved in positively modulating the rate of age-related behavioral deterioration (PubMed:32103178).
May repress the expression of mitochondrial function-related genes by occupying their promoter regions, working in concert with probable chromatin reader protein, baz-2 (PubMed:32103178).
Involved in modulation of the mitochondrial unfolded protein response (UPR) (PubMed:32103178).
Regulates level of expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase) (PubMed:32103178).
Negatively modulates levels of endogenous 5-HT and dopamine with aging (PubMed:32103178).
Involved in modulating longevity, probably as a result of enhanced stress resistance via mechanisms related to dietary restriction and mitochondrial function (PubMed:32103178).
May repress the expression of mitochondrial function-related genes by occupying their promoter regions, working in concert with probable chromatin reader protein, baz-2 (PubMed:32103178).
Involved in modulation of the mitochondrial unfolded protein response (UPR) (PubMed:32103178).
Regulates level of expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase) (PubMed:32103178).
Negatively modulates levels of endogenous 5-HT and dopamine with aging (PubMed:32103178).
Involved in modulating longevity, probably as a result of enhanced stress resistance via mechanisms related to dietary restriction and mitochondrial function (PubMed:32103178).
Catalytic activity
- N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine + H+
RHEA-COMP:15542 CHEBI:61929 Position: 9+ CHEBI:59789 = RHEA-COMP:15541 CHEBI:61976 Position: 9+ CHEBI:57856 + CHEBI:15378
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | nucleus | |
Molecular Function | histone H3K9 dimethyltransferase activity | |
Molecular Function | histone H3K9 trimethyltransferase activity | |
Molecular Function | histone H3K9me2 methyltransferase activity | |
Biological Process | epigenetic regulation of gene expression | |
Biological Process | methylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone-lysine N-methyltransferase set-6
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionO17679
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000452178 | 1-708 | Histone-lysine N-methyltransferase set-6 | |||
Sequence: MERSRTGGSSTYSMSTANVPIITISDDDDELTIWEEPRKSPISSNSYSDERNHSLSSTSNSSVERSIIITISDDESEATERNQQEVVDRAISNNLTEKRRRSVESFHRLHSKERKLEVKSRKKSRTSSSSMEASTSCTFPARQTKTKRHKRKTYSTISSFAPHHSTICAELRNVNPARIADFRHPSIFEYSDMSLNERREHWKKEMKVIKKHNDIRLMHEEAVRFDDIIELDPTLNGYYRRFMGAEQSTRALFMAVRCLATFGRNFYEEPERDHGEEEIPEELDRYFEKLIYVAPRTRIRITDDIHLSNDTHRIPVYTDAKGETLKTVKIPNPLLYDHIINNMVDKVKEPLLYEAIKIAGSSENVIRCKCCSQDPVVNCFDNKDCPCFIANQFLQSRNKTTDTNEKLKFHTFQPLMYNDGNPTYYNTVGFACSPKCACKGACTNNATYLIQKKLYSIEIYRADPQIGFGIRSTLFIPAGTPIIEYCGELVDGERLHSSLENYSYQLTDCEGDKHLYNLLREKYKNNPEYYDVLDELSKHHFHLDAKMQGSVGRFANHSCTPNMEPLRLFKEGFTPANMRMIFFTLKDIFPGEPLTLDYGSEYKVFRRQRCLCRTFACRSGPHYEKFSNLDGKLIASCFVRLHHASRIRYSVDLQLIERFYSVGKVEEVRVDPCVSFSKYNLKWRRQLSTATCERLENVIEIELSDEDS |
Proteomic databases
Expression
Tissue specificity
Broadly expressed in the nervous system, including head, body and tail neurons.
Developmental stage
Expression increases with age.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 36-63 | Disordered | ||||
Sequence: EPRKSPISSNSYSDERNHSLSSTSNSSV | ||||||
Compositional bias | 38-63 | Polar residues | ||||
Sequence: RKSPISSNSYSDERNHSLSSTSNSSV | ||||||
Region | 101-152 | Disordered | ||||
Sequence: RSVESFHRLHSKERKLEVKSRKKSRTSSSSMEASTSCTFPARQTKTKRHKRK | ||||||
Compositional bias | 127-142 | Polar residues | ||||
Sequence: SSSSMEASTSCTFPAR | ||||||
Domain | 455-599 | SET | ||||
Sequence: YSIEIYRADPQIGFGIRSTLFIPAGTPIIEYCGELVDGERLHSSLENYSYQLTDCEGDKHLYNLLREKYKNNPEYYDVLDELSKHHFHLDAKMQGSVGRFANHSCTPNMEPLRLFKEGFTPANMRMIFFTLKDIFPGEPLTLDYG |
Sequence similarities
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length708
- Mass (Da)82,093
- Last updated2002-10-01 v2
- ChecksumCF4B968F8BB88312
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 38-63 | Polar residues | ||||
Sequence: RKSPISSNSYSDERNHSLSSTSNSSV | ||||||
Compositional bias | 127-142 | Polar residues | ||||
Sequence: SSSSMEASTSCTFPAR |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284606 EMBL· GenBank· DDBJ | CAB03974.2 EMBL· GenBank· DDBJ | Genomic DNA |