O17554 · ALKMO_CAEEL
- ProteinAlkylglycerol monooxygenase
- Geneagmo-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids505 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids.
Catalytic activity
- (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2O
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | glyceryl-ether monooxygenase activity | |
Molecular Function | iron ion binding | |
Biological Process | lipid biosynthetic process | |
Biological Process | membrane lipid metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlkylglycerol monooxygenase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionO17554
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 56-76 | Helical | ||||
Sequence: VSAWWLVFLTAEFFILFISGH | ||||||
Transmembrane | 104-124 | Helical | ||||
Sequence: AVAIFLYVIVWDNWRILELPW | ||||||
Transmembrane | 366-386 | Helical | ||||
Sequence: ILVKVYVASSFLLLLAIFFHF | ||||||
Transmembrane | 396-416 | Helical | ||||
Sequence: LDCTVKIAYFVVTMQCFGAFF | ||||||
Transmembrane | 430-450 | Helical | ||||
Sequence: CCGVLIYYGVLMFDHIGAGTH | ||||||
Transmembrane | 452-472 | Helical | ||||
Sequence: LFVISLHIMAIALWTTDVLVE |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000299305 | 1-505 | Alkylglycerol monooxygenase | |||
Sequence: MNETAWLDRVFSNTSLGHRLLDRLTLTNLRHAFYLISPYETTVESIDDVPNYNAEVSAWWLVFLTAEFFILFISGHEDRFALNDSITSICAGMLSQCFKFGGRAVAIFLYVIVWDNWRILELPWDSPWTWIFCLFFQDFMYYLGHRAVHEAGFFWGLHTIHHSSEYYNFSTALRQAAIQDAGLAIYDCIQAFFIPPSIFLVHRYFSEIFQFIMHTSLVDTMGPLGLVFNTPSHHRVHHGRNPYCIDKNYGGVFIIWDKMFNTFEAERHDDPPIYGLVTNENTFNQIYLQFHALWDILIFKGFTKDVKGEPMFPGVVNKLKATVFPPGWFPGVPVTPFFHWMSMVNPAHGVPEPEKPVLRYSPPARILVKVYVASSFLLLLAIFFHFEYDRNHLSYLDCTVKIAYFVVTMQCFGAFFDMKWYARYIEIARCCGVLIYYGVLMFDHIGAGTHRLFVISLHIMAIALWTTDVLVEKLSQCCSKNQSINPEKGDLERAPEIASISKNVQ |
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 130-262 | Fatty acid hydroxylase | ||||
Sequence: WIFCLFFQDFMYYLGHRAVHEAGFFWGLHTIHHSSEYYNFSTALRQAAIQDAGLAIYDCIQAFFIPPSIFLVHRYFSEIFQFIMHTSLVDTMGPLGLVFNTPSHHRVHHGRNPYCIDKNYGGVFIIWDKMFNT | ||||||
Motif | 145-149 | Histidine box-1 | ||||
Sequence: HRAVH | ||||||
Motif | 158-162 | Histidine box-2 | ||||
Sequence: HTIHH | ||||||
Motif | 234-238 | Histidine box-3 | ||||
Sequence: HRVHH |
Sequence similarities
Belongs to the sterol desaturase family. TMEM195 subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length505
- Mass (Da)58,491
- Last updated2002-10-01 v2
- Checksum22C40C34FBA42820
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z93372 EMBL· GenBank· DDBJ | CAB07547.2 EMBL· GenBank· DDBJ | Genomic DNA |