O16991 · TF2B_CAEEL
- ProteinTranscription initiation factor IIB
- Genettb-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids306 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II) (By similarity).
Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (By similarity).
Essential for early embryonic development (PubMed:11566890).
Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA (By similarity).
Essential for early embryonic development (PubMed:11566890).
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | transcription preinitiation complex | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II general transcription initiation factor activity | |
Molecular Function | TBP-class protein binding | |
Biological Process | transcription initiation at RNA polymerase II promoter | |
Biological Process | transcription preinitiation complex assembly |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTranscription initiation factor IIB
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionO16991
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
RNAi-mediated knockdown causes arrested development at 90-100 cells and inhibits differentiation (PubMed:11566890).
The two E cell daughters (E2 cells), which form the endoderm, divide abnormally early, immediately after the MS2 cells (PubMed:11566890).
Phosphorylation of the RNA Pol II large subunit C-terminal domain (CTD) is reduced severely in embryos (PubMed:11566890).
The two E cell daughters (E2 cells), which form the endoderm, divide abnormally early, immediately after the MS2 cells (PubMed:11566890).
Phosphorylation of the RNA Pol II large subunit C-terminal domain (CTD) is reduced severely in embryos (PubMed:11566890).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000119298 | 1-306 | Transcription initiation factor IIB | |||
Sequence: MSAPVQCPIHPDVHLIEDHRAGDLVCPACGLVVGDRLVDVGTEWRSFSNERSGNDPSRVGAPENPLLSGGDLSTTIAVGFGGSDSDNSLANAQRKSMNNTDRQMTAAMSLIREMSERIHLPRNIQDSASRIFKDVLESKALRGKNNEAQAAACLYIACRKDGVPRTFKEICAVSRVSKKEIGRCFKIIVRSLETNLEQITSADFMSRFCGNLSLPNSIQAAATRIAKCAVDMDLVAGRTPISIAAAAIYMASQASAEKRSAKEIGDVAGAAEITVRQTYKLLYPKALELFPKDFRFVTPIDALPNS |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for zinc finger, region, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 3-34 | TFIIB-type | ||||
Sequence: APVQCPIHPDVHLIEDHRAGDLVCPACGLVVG | ||||||
Region | 47-66 | Disordered | ||||
Sequence: FSNERSGNDPSRVGAPENPL | ||||||
Repeat | 114-190 | 1 | ||||
Sequence: MSERIHLPRNIQDSASRIFKDVLESKALRGKNNEAQAAACLYIACRKDGVPRTFKEICAVSRVSKKEIGRCFKIIVR | ||||||
Repeat | 208-284 | 2 | ||||
Sequence: FCGNLSLPNSIQAAATRIAKCAVDMDLVAGRTPISIAAAAIYMASQASAEKRSAKEIGDVAGAAEITVRQTYKLLYP |
Sequence similarities
Belongs to the TFIIB family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length306
- Mass (Da)33,102
- Last updated2001-10-01 v2
- ChecksumACA6B94A8A5A8D59
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FO081767 EMBL· GenBank· DDBJ | CCD74279.1 EMBL· GenBank· DDBJ | Genomic DNA |