O16810 · ORC1_DROME
- ProteinOrigin recognition complex subunit 1
- GeneOrc1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids924 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 564 | ATP (UniProtKB | ChEBI) | |||
Binding site | 598-606 | ATP (UniProtKB | ChEBI) | |||
Binding site | 684 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 685 | ATP (UniProtKB | ChEBI) | |||
Binding site | 685 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 718 | ATP (UniProtKB | ChEBI) | |||
Binding site | 784 | ATP (UniProtKB | ChEBI) | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nuclear origin of replication recognition complex | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | chromatin binding | |
Molecular Function | DNA binding | |
Molecular Function | metal ion binding | |
Biological Process | DNA amplification | |
Biological Process | DNA replication initiation | |
Biological Process | mitotic DNA replication checkpoint signaling |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrigin recognition complex subunit 1
- Short namesDmORC1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionO16810
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000127069 | 1-924 | Origin recognition complex subunit 1 | ||
Modified residue | 293 | Phosphoserine | |||
Modified residue | 368 | Phosphoserine | |||
Modified residue | 419 | Phosphothreonine | |||
Modified residue | 426 | Phosphoserine | |||
Modified residue | 430 | Phosphoserine | |||
Modified residue | 533 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
ORC is composed of six subunits.
Complex viewer
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 45-187 | BAH | |||
Compositional bias | 196-237 | Basic and acidic residues | |||
Region | 196-239 | Disordered | |||
Region | 377-440 | Disordered | |||
Compositional bias | 412-437 | Polar residues | |||
Compositional bias | 460-485 | Basic and acidic residues | |||
Region | 460-523 | Disordered | |||
Compositional bias | 491-521 | Polar residues | |||
Sequence similarities
Belongs to the ORC1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length924
- Mass (Da)103,281
- Last updated2001-02-21 v2
- ChecksumAACD002DEB10A136
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 159 | in Ref. 1; AAC47802 | |||
Compositional bias | 196-237 | Basic and acidic residues | |||
Compositional bias | 412-437 | Polar residues | |||
Compositional bias | 460-485 | Basic and acidic residues | |||
Compositional bias | 491-521 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF017647 EMBL· GenBank· DDBJ | AAC47802.1 EMBL· GenBank· DDBJ | mRNA | ||
AE013599 EMBL· GenBank· DDBJ | AAF59236.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY094780 EMBL· GenBank· DDBJ | AAM11133.1 EMBL· GenBank· DDBJ | mRNA |