results demonstrated that PLAUR induces geftinib-resistance through EGFR/p-AKT/survivin signaling pathway in gefitinib-resistant human lung adenocarcinoma cells. PLAUR could be a novel therapeutic target for gefitinib-resistant NSCLC patients.
suggests SIRT1 may serve as a predictor of poor prognosis in esophageal squamous cell carcinoma and its mediated tumor-promoting role might be associated with the overexpression of EGFR protein in esophageal squamous cell carcinoma
Survivin p53 and beta-catenin overexpression as prognostic markers might suggest that the Urothelial carcinomas are biologically aggressive with the poor prognosis
results suggest that high-grade glioma expressing high level of alpha5beta1 integrin may benefit from associated therapies including integrin antagonists and repressors of survivin expression.
this study documented down-regulation of galectin-3 and Bcl-2 (antiapoptotic molecules) and stepwise increase of survivin (inhibitor of apoptosis) during thyroid tumor progression from PTC to ATC.
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