O15209 · ZBT22_HUMAN
- ProteinZinc finger and BTB domain-containing protein 22
- GeneZBTB22
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids634 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be involved in transcriptional regulation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | sequence-specific double-stranded DNA binding | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameZinc finger and BTB domain-containing protein 22
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO15209
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_057457 | 250 | in dbSNP:rs35663442 | |||
Sequence: G → A | ||||||
Natural variant | VAR_022702 | 310 | in dbSNP:rs3130100 | |||
Sequence: T → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,178 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000047517 | 1-634 | UniProt | Zinc finger and BTB domain-containing protein 22 | |||
Sequence: MEPSPLSPSGAALPLPLSLAPPPLPLPAAAVVHVSFPEVTSALLESLNQQRLQGQLCDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAAADIVNFLTVGSVLQMWHIVDKCTELLREGRASATTTITTAAATSVTVPGAGVPSGSGGTVAPATMGSARSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAASAVGSGERRGGGPVFPAPVVGSGGATSGKLLLEADELCDDGGDGRGAVVPGAGLRRPTYTPPSIMPQKHWVYVKRGGNCPAPTPLVPQDPDLEEEEEEEDLVLTCEDDEDEELGGSSRVPVGGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGPVAGLDDSGGPTPSSYAPSHPPRPLLPLDMQGNQILVFPSSSSSSSSQAPGQPPGNQAEHGAVTVGGTSVGSLGVPGSVGGVPGGTGSGDGNKIFLCHCGKAFSHKSMRDRHVNMHLNLRPFDCPVCNKKFKMKHHLTEHMKTHTGLKPYECGVCAKKFMWRDSFMRHRGHCERRHRLGGVGAVPGPGTPTGPSLPSKRESPGVGGGSGDEASAATPPSSRRVWSPPRVHKVEMGFGGGGGAN | |||||||
Modified residue (large scale data) | 198 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 202 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 202 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 592 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 599 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O15209 | A8KA83 | 3 | EBI-723574, EBI-10174961 | |
BINARY | O15209 | CCDC13 Q8IYE1 | 3 | EBI-723574, EBI-10961312 | |
BINARY | O15209 | FXR2 P51116 | 3 | EBI-723574, EBI-740459 | |
BINARY | O15209 | GABARAPL1 Q9H0R8 | 4 | EBI-723574, EBI-746969 | |
BINARY | O15209 | GAS8 O95995 | 3 | EBI-723574, EBI-1052570 | |
BINARY | O15209 | MCRS1 Q96EZ8 | 6 | EBI-723574, EBI-348259 | |
BINARY | O15209 | MEMO1 Q9Y316 | 3 | EBI-723574, EBI-1104564 | |
BINARY | O15209 | MLLT6 Q6P2C6 | 3 | EBI-723574, EBI-5773143 | |
BINARY | O15209 | PIN1 Q13526 | 3 | EBI-723574, EBI-714158 | |
BINARY | O15209 | RBM39 Q14498-3 | 3 | EBI-723574, EBI-6654703 | |
BINARY | O15209 | TCEA2 Q15560 | 3 | EBI-723574, EBI-710310 | |
BINARY | O15209 | VAPA Q9P0L0 | 3 | EBI-723574, EBI-1059156 | |
BINARY | O15209 | VAPB O95292 | 3 | EBI-723574, EBI-1188298 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 57-121 | BTB | ||||
Sequence: CDVSIRVQGREFRAHRAVLAASSPYFHDQVLLKGMTSISLPSVMDPGAFETVLASAYTGRLSMAA | ||||||
Region | 167-247 | Disordered | ||||
Sequence: TVPGAGVPSGSGGTVAPATMGSARSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAASAVGSGERRGGGPVFPAPVV | ||||||
Compositional bias | 181-227 | Polar residues | ||||
Sequence: VAPATMGSARSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAA | ||||||
Region | 308-461 | Disordered | ||||
Sequence: APTPLVPQDPDLEEEEEEEDLVLTCEDDEDEELGGSSRVPVGGGPEATLSISDVRTLSEPPDKGEEQVNFCESSNDFGPYEGGGPVAGLDDSGGPTPSSYAPSHPPRPLLPLDMQGNQILVFPSSSSSSSSQAPGQPPGNQAEHGAVTVGGTSV | ||||||
Compositional bias | 316-340 | Acidic residues | ||||
Sequence: DPDLEEEEEEEDLVLTCEDDEDEEL | ||||||
Compositional bias | 425-445 | Polar residues | ||||
Sequence: QILVFPSSSSSSSSQAPGQPP | ||||||
Zinc finger | 486-507 | C2H2-type 1; atypical | ||||
Sequence: FLCHCGKAFSHKSMRDRHVNMH | ||||||
Zinc finger | 513-535 | C2H2-type 2 | ||||
Sequence: FDCPVCNKKFKMKHHLTEHMKTH | ||||||
Zinc finger | 541-562 | C2H2-type 3 | ||||
Sequence: YECGVCAKKFMWRDSFMRHRGH | ||||||
Region | 568-634 | Disordered | ||||
Sequence: RLGGVGAVPGPGTPTGPSLPSKRESPGVGGGSGDEASAATPPSSRRVWSPPRVHKVEMGFGGGGGAN |
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length634
- Mass (Da)65,602
- Last updated1998-01-01 v1
- Checksum9CC1867213D6DEF7
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A2AB93 | A2AB93_HUMAN | ZBTB22 | 149 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 181-227 | Polar residues | ||||
Sequence: VAPATMGSARSHASSRASENQSPSSSNYFSPRESTDFSSSSQEAFAA | ||||||
Compositional bias | 316-340 | Acidic residues | ||||
Sequence: DPDLEEEEEEEDLVLTCEDDEDEEL | ||||||
Compositional bias | 425-445 | Polar residues | ||||
Sequence: QILVFPSSSSSSSSQAPGQPP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z97183 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
Z97184 EMBL· GenBank· DDBJ | CAB09990.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK315747 EMBL· GenBank· DDBJ | BAG38101.1 EMBL· GenBank· DDBJ | mRNA | ||
AL662820 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL662827 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX248088 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR759786 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR759817 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471081 EMBL· GenBank· DDBJ | EAX03721.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC018541 EMBL· GenBank· DDBJ | AAH18541.1 EMBL· GenBank· DDBJ | mRNA |