O15016 · TRI66_HUMAN

  • Protein
    Tripartite motif-containing protein 66
  • Gene
    TRIM66
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

Features

Showing features for binding site.

113511002003004005006007008009001,0001,1001,2001,300
TypeIDPosition(s)Description
Binding site109Zn2+ 1 (UniProtKB | ChEBI)
Binding site112Zn2+ 1 (UniProtKB | ChEBI)
Binding site133Zn2+ 1 (UniProtKB | ChEBI)
Binding site139Zn2+ 1 (UniProtKB | ChEBI)
Binding site169Zn2+ 2 (UniProtKB | ChEBI)
Binding site172Zn2+ 2 (UniProtKB | ChEBI)
Binding site192Zn2+ 2 (UniProtKB | ChEBI)
Binding site197Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentchromatin
Cellular Componentnucleus
Molecular Functionzinc ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tripartite motif-containing protein 66

Gene names

    • Name
      TRIM66
    • Synonyms
      C11orf29, KIAA0298

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O15016
  • Secondary accessions
    • A0A2R8YEA1
    • Q9BQQ4

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Note: Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm.

Keywords

Disease & Variants

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002203751-1351Tripartite motif-containing protein 66

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif (By similarity).

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for zinc finger, coiled coil, compositional bias, region, motif, domain.

TypeIDPosition(s)Description
Zinc finger105-150B box-type 1; atypical
Zinc finger164-205B box-type 2
Coiled coil234-304
Compositional bias542-557Polar residues
Region542-608Disordered
Compositional bias558-589Pro residues
Compositional bias663-682Polar residues
Region663-730Disordered
Compositional bias711-730Polar residues
Compositional bias857-884Polar residues
Region857-895Disordered
Motif995-999PxVxL motif
Region1067-1098Disordered
Zinc finger1105-1152PHD-type
Domain1191-1263Bromo
Region1289-1351Disordered
Compositional bias1323-1340Basic and acidic residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

O15016-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,351
  • Mass (Da)
    149,469
  • Last updated
    2022-12-14 v5
  • Checksum
    EC3AC054A2720E04
MSFMGLPLAGQKHCPKSGQMEAMVMTCSLCHQDLPGMGSHLLSCQHLLRKDCFQGLIQELGQIAKAHETVADELISCPGCERVYLTRDVTEHFFLHCVPTEQPKMARNCSECKEKRAAHILCTYCNRWLCSSCTEEHRHSPVPGGPFFPRAQKGSPGVNGGPGDFTLYCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQVAHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNTDPGSPWSIRFTWEPNFWTKQLASLGCITTEGGQMSRADAPAYGGLQGSSPFYQSHQSPVAQQEALSHPSHKFQSPAVCSSSVCCSHCSPVSPSLKGQVPPPSIHPAHSFRQPPEMVPQQLGSLQCSALLPREKELACSPHPPKLLQPWLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQQGAHAQPTLQTPSIQVQFGHHQKLKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHPPLPPSQHLASSQHESPPGPACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAALPQASGEETPLSVPPVDSTIQHSSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPSLLSAPPKMVSSLTSVQNQAMPSLTTSHLQTVPSLVHSTFQSMPNLISDSPQAMASLASDHPQAGPSLMSGHTQAVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGSLCPRDGADPSLENALCKMESEDSTRFTDLLGQGPIVPGLDAPKDLAIPSELEEPINLSVKKPPLAPVVSTSTALQQYQNPKECENFEQGALELDAKENQSIRAFNSEHKIPYVRLERLKICAASSGEMPVFKLKPQKNDQDGSFLLIIECGTESSSMSIKVSQDRLSEATQAPGLEGRKVTVTSLAGQRPPEVEGTSPEEHRLIPRTPGAKKGPPAPIENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDCENACYNQPGMRASPGLSMYDQKKCEKLVLSLCCNNLSLPFHEPVSPLARHYYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEIYPEKRFAQPRQEDSDSEEVSSESGCSTPQGFPWPPYMQEGIQPKRRRRHMENERAKRMSFRLANSISQV

O15016-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

O15016-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-104: Missing
    • 902-972: MESEDSTRFTDLLGQGPIVPGLDAPKDLAIPSELEEPINLSVKKPPLAPVVSTSTALQQYQNPKECENFEQ → VSPGEMLSKLPLFIIGQKIGHWDPYSDLSLTVLRPLMTTMSEFFDSCRHFTFERWKVRIPLASLTYWDKVP
    • 973-1351: Missing

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R8YE93A0A2R8YE93_HUMANTRIM6636
H0YF52H0YF52_HUMANTRIM66329
B5MCJ9B5MCJ9_HUMANTRIM6630
A0A8Z5E822A0A8Z5E822_HUMANTRIM661392
A0A994J7V7A0A994J7V7_HUMANTRIM661247
A0A994J5L5A0A994J5L5_HUMANTRIM661239
A0A994J572A0A994J572_HUMANTRIM661355

Sequence caution

The sequence BAA20758.2 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0616771-104in isoform 2 and isoform 3
Alternative sequenceVSP_061678201-202in isoform 2
Compositional bias542-557Polar residues
Compositional bias558-589Pro residues
Compositional bias663-682Polar residues
Compositional bias711-730Polar residues
Compositional bias857-884Polar residues
Alternative sequenceVSP_061680902-934in isoform 2
Alternative sequenceVSP_061679902-972in isoform 3
Alternative sequenceVSP_061681973-1351in isoform 3
Compositional bias1323-1340Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ400879
EMBL· GenBank· DDBJ
CAC35389.1
EMBL· GenBank· DDBJ
Genomic DNA
AB002296
EMBL· GenBank· DDBJ
BAA20758.2
EMBL· GenBank· DDBJ
mRNA Different initiation
AC091053
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC104360
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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