O15016 · TRI66_HUMAN
- ProteinTripartite motif-containing protein 66
- GeneTRIM66
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1351 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 109 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 112 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 133 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 139 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 169 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 172 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 192 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 197 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | nucleus | |
Molecular Function | zinc ion binding |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTripartite motif-containing protein 66
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO15016
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000220375 | 1-1351 | Tripartite motif-containing protein 66 | |||
Sequence: MSFMGLPLAGQKHCPKSGQMEAMVMTCSLCHQDLPGMGSHLLSCQHLLRKDCFQGLIQELGQIAKAHETVADELISCPGCERVYLTRDVTEHFFLHCVPTEQPKMARNCSECKEKRAAHILCTYCNRWLCSSCTEEHRHSPVPGGPFFPRAQKGSPGVNGGPGDFTLYCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHVEEVLQNQRMLLEGVTTQVAHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLETSCNTDPGSPWSIRFTWEPNFWTKQLASLGCITTEGGQMSRADAPAYGGLQGSSPFYQSHQSPVAQQEALSHPSHKFQSPAVCSSSVCCSHCSPVSPSLKGQVPPPSIHPAHSFRQPPEMVPQQLGSLQCSALLPREKELACSPHPPKLLQPWLETQPPVEQESTSQRLGQQLTSQPVCIVPPQDVQQGAHAQPTLQTPSIQVQFGHHQKLKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHPPLPPSQHLASSQHESPPGPACSQNMDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAALPQASGEETPLSVPPVDSTIQHSSPNVVRKHSTSLSIMGFSNTLEMELSSTRLERPLEPQIQSVSNLTAGAPQAVPSLLSAPPKMVSSLTSVQNQAMPSLTTSHLQTVPSLVHSTFQSMPNLISDSPQAMASLASDHPQAGPSLMSGHTQAVPSLATCPLQSIPPVSDMQPETGSSSSSGRTSGSLCPRDGADPSLENALCKMESEDSTRFTDLLGQGPIVPGLDAPKDLAIPSELEEPINLSVKKPPLAPVVSTSTALQQYQNPKECENFEQGALELDAKENQSIRAFNSEHKIPYVRLERLKICAASSGEMPVFKLKPQKNDQDGSFLLIIECGTESSSMSIKVSQDRLSEATQAPGLEGRKVTVTSLAGQRPPEVEGTSPEEHRLIPRTPGAKKGPPAPIENEDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDCENACYNQPGMRASPGLSMYDQKKCEKLVLSLCCNNLSLPFHEPVSPLARHYYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEIYPEKRFAQPRQEDSDSEEVSSESGCSTPQGFPWPPYMQEGIQPKRRRRHMENERAKRMSFRLANSISQV |
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for zinc finger, coiled coil, compositional bias, region, motif, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 105-150 | B box-type 1; atypical | ||||
Sequence: MARNCSECKEKRAAHILCTYCNRWLCSSCTEEHRHSPVPGGPFFPR | ||||||
Zinc finger | 164-205 | B box-type 2 | ||||
Sequence: DFTLYCPLHTQEVLKLFCETCDMLTCHSCLVVEHKEHRCRHV | ||||||
Coiled coil | 234-304 | |||||
Sequence: AKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKRKLEQQLQSIMVLNRQFEH | ||||||
Compositional bias | 542-557 | Polar residues | ||||
Sequence: FGHHQKLKLSHFQQQP | ||||||
Region | 542-608 | Disordered | ||||
Sequence: FGHHQKLKLSHFQQQPQQQLPPPPPPLPHPPPPLPPPPQQPHPPLPPSQHLASSQHESPPGPACSQN | ||||||
Compositional bias | 558-589 | Pro residues | ||||
Sequence: QQQLPPPPPPLPHPPPPLPPPPQQPHPPLPPS | ||||||
Compositional bias | 663-682 | Polar residues | ||||
Sequence: APVQSQSQEETLQATDEPPA | ||||||
Region | 663-730 | Disordered | ||||
Sequence: APVQSQSQEETLQATDEPPASQGSKPALPLDKNTAAALPQASGEETPLSVPPVDSTIQHSSPNVVRKH | ||||||
Compositional bias | 711-730 | Polar residues | ||||
Sequence: SVPPVDSTIQHSSPNVVRKH | ||||||
Compositional bias | 857-884 | Polar residues | ||||
Sequence: CPLQSIPPVSDMQPETGSSSSSGRTSGS | ||||||
Region | 857-895 | Disordered | ||||
Sequence: CPLQSIPPVSDMQPETGSSSSSGRTSGSLCPRDGADPSL | ||||||
Motif | 995-999 | PxVxL motif | ||||
Sequence: PYVRL | ||||||
Region | 1067-1098 | Disordered | ||||
Sequence: TSLAGQRPPEVEGTSPEEHRLIPRTPGAKKGP | ||||||
Zinc finger | 1105-1152 | PHD-type | ||||
Sequence: EDFCAVCLNGGELLCCDRCPKVFHLSCHVPALLSFPGGEWVCTLCRSL | ||||||
Domain | 1191-1263 | Bromo | ||||
Sequence: SLCCNNLSLPFHEPVSPLARHYYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSE | ||||||
Region | 1289-1351 | Disordered | ||||
Sequence: AQPRQEDSDSEEVSSESGCSTPQGFPWPPYMQEGIQPKRRRRHMENERAKRMSFRLANSISQV | ||||||
Compositional bias | 1323-1340 | Basic and acidic residues | ||||
Sequence: IQPKRRRRHMENERAKRM |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
O15016-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,351
- Mass (Da)149,469
- Last updated2022-12-14 v5
- ChecksumEC3AC054A2720E04
O15016-2
- Name2
O15016-3
- Name3
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8YE93 | A0A2R8YE93_HUMAN | TRIM66 | 36 | ||
H0YF52 | H0YF52_HUMAN | TRIM66 | 329 | ||
B5MCJ9 | B5MCJ9_HUMAN | TRIM66 | 30 | ||
A0A8Z5E822 | A0A8Z5E822_HUMAN | TRIM66 | 1392 | ||
A0A994J7V7 | A0A994J7V7_HUMAN | TRIM66 | 1247 | ||
A0A994J5L5 | A0A994J5L5_HUMAN | TRIM66 | 1239 | ||
A0A994J572 | A0A994J572_HUMAN | TRIM66 | 1355 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_061677 | 1-104 | in isoform 2 and isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_061678 | 201-202 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 542-557 | Polar residues | ||||
Sequence: FGHHQKLKLSHFQQQP | ||||||
Compositional bias | 558-589 | Pro residues | ||||
Sequence: QQQLPPPPPPLPHPPPPLPPPPQQPHPPLPPS | ||||||
Compositional bias | 663-682 | Polar residues | ||||
Sequence: APVQSQSQEETLQATDEPPA | ||||||
Compositional bias | 711-730 | Polar residues | ||||
Sequence: SVPPVDSTIQHSSPNVVRKH | ||||||
Compositional bias | 857-884 | Polar residues | ||||
Sequence: CPLQSIPPVSDMQPETGSSSSSGRTSGS | ||||||
Alternative sequence | VSP_061680 | 902-934 | in isoform 2 | |||
Sequence: MESEDSTRFTDLLGQGPIVPGLDAPKDLAIPSE → VK | ||||||
Alternative sequence | VSP_061679 | 902-972 | in isoform 3 | |||
Sequence: MESEDSTRFTDLLGQGPIVPGLDAPKDLAIPSELEEPINLSVKKPPLAPVVSTSTALQQYQNPKECENFEQ → VSPGEMLSKLPLFIIGQKIGHWDPYSDLSLTVLRPLMTTMSEFFDSCRHFTFERWKVRIPLASLTYWDKVP | ||||||
Alternative sequence | VSP_061681 | 973-1351 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 1323-1340 | Basic and acidic residues | ||||
Sequence: IQPKRRRRHMENERAKRM |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ400879 EMBL· GenBank· DDBJ | CAC35389.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB002296 EMBL· GenBank· DDBJ | BAA20758.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AC091053 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC104360 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |