O14904 · WNT9A_HUMAN

  • Protein
    Protein Wnt-9a
  • Gene
    WNT9A
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentextracellular space
Molecular Functioncytokine activity
Molecular Functionfrizzled binding
Molecular Functionreceptor ligand activity
Biological Processcanonical Wnt signaling pathway
Biological Processcell fate commitment
Biological Processcellular response to retinoic acid
Biological Processcornea development in camera-type eye
Biological Processembryonic skeletal joint development
Biological Processiris morphogenesis
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of chondrocyte differentiation
Biological Processneuron differentiation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein Wnt-9a
  • Alternative names
    • Protein Wnt-14

Gene names

    • Name
      WNT9A
    • Synonyms
      WNT14

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O14904
  • Secondary accessions
    • A6NLW2
    • Q2M2J3
    • Q5VWU0
    • Q96S50

Proteomes

Organism-specific databases

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_052956260in dbSNP:rs8192633

Variants

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The viewer provides 446 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, lipidation.

TypeIDPosition(s)Description
Signal1-29
ChainPRO_000004145530-365Protein Wnt-9a
Disulfide bond93↔104
Glycosylation103N-linked (GlcNAc...) asparagine
Disulfide bond141↔149
Disulfide bond151↔168
Disulfide bond215↔229
Disulfide bond217↔224
Lipidation221O-palmitoleoyl serine; by PORCN
Disulfide bond299↔324
Disulfide bond313↔319
Disulfide bond323↔363
Disulfide bond339↔354
Disulfide bond341↔351
Disulfide bond346↔347

Post-translational modification

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720).
The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY O14904ZBTB14 O438293EBI-12053451, EBI-10176632

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region260-287Disordered

Sequence similarities

Belongs to the Wnt family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    365
  • Mass (Da)
    40,320
  • Last updated
    2002-05-10 v2
  • Checksum
    1E1284D744C6A9B2
MLDGSPLARWLAAAFGLTLLLAALRPSAAYFGLTGSEPLTILPLTLEPEAAAQAHYKACDRLKLERKQRRMCRRDPGVAETLVEAVSMSALECQFQFRFERWNCTLEGRYRASLLKRGFKETAFLYAISSAGLTHALAKACSAGRMERCTCDEAPDLENREAWQWGGCGDNLKYSSKFVKEFLGRRSSKDLRARVDFHNNLVGVKVIKAGVETTCKCHGVSGSCTVRTCWRQLAPFHEVGKHLKHKYETALKVGSTTNEAAGEAGAISPPRGRASGAGGSDPLPRTPELVHLDDSPSFCLAGRFSPGTAGRRCHREKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECRQCTQREEVYTCKG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB060283
EMBL· GenBank· DDBJ
BAB61051.1
EMBL· GenBank· DDBJ
mRNA
AL360269
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471098
EMBL· GenBank· DDBJ
EAW69821.1
EMBL· GenBank· DDBJ
Genomic DNA
BC111960
EMBL· GenBank· DDBJ
AAI11961.1
EMBL· GenBank· DDBJ
mRNA
BC113431
EMBL· GenBank· DDBJ
AAI13432.1
EMBL· GenBank· DDBJ
mRNA
AF028702
EMBL· GenBank· DDBJ
AAC39550.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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